The fixture could be the first for Sheffield without boss Chris Wilder after rumours that he has left his position as manager of the Blades by mutual consent on Friday and will be replaced by caretaker boss Paul Heckingbottom in the dugout.
After last season's excellent campaign for United, this season hasn't quite lived up to the same lofty heights and with the Yorkshire outfit rooted to the bottom of the table, three points will only do whilst Leicester look to continue to assert their place in the top-four.
The visitors have yet to beat Leicester in the top-flight since returning in 2019 and their first meeting of that year in August saw Brendan Rodgers and his side claim their first three points of the season at a sun-baked Bramall Lane
Vardy fires Foxes in front
With any newly-promoted side, it is always a difficult fixture to face early on in the season, and Wilder's side were no different, demonstrating a disciplined and organised approach to the game.
Despite restricting the visitors early on, it was Leicester who took the lead. After pressuring Chris Basham into winning the ball back, Ayoze Perez was able to find the feet of James Maddison.
Creating space to move away from the on-rushing defenders, Maddison was able to pick out Jamie Vardy with a beautifully-weighted through ball with the outside of his boot.
Vardy was able to race through on goal, taking his time to pick out his spot before the boyhood Sheffield Wednesday fan fired the ball into the roof of the net, taunting the opposition supporters by cupping his ears to the crowd.
First goal for new signing finds the Blades an equaliser
At the time of the game, striker Oli McBurnie had just become Sheffield United's record signing after joining from Swansea City for a record fee of £20m and made an instant impact as a second-half substitute.
With the roar of the Sheffield crowd behind the side in what was their first Premier league home game in 12 years, they were able to find the leveller after George Baldock's teasing ball was whipped into the box.
Utilising his strengths, McBurnie was able to rise highest, beating Kasper Schmeichel to the ball to guide the header low into the bottom corner and send the stands into raptures.
Barnes super-strike wins the game
With both sides cancelling each other out, it was going to take a moment of brilliance from either team to win the game. Step forward Harvey Barnes.
Now a regular name in the starting XI, Barnes came off the bench for this game and had the final say as his brilliant effort secured the three points 20 minutes from time.
Following a Foxes corner, Christian Fuchs was able to retrieve possession and fire a ball back into the box. Finding the head of Caglar Soyuncu, the Turkey international's effort ballooned into the air.
Watching the ball come back down, Barnes was in the right place at the right time just inside the box, connecting with the ball on the half-volley, sending it flying past Dean Henderson to give him no chance of saving the shot.
The goal was enough for the East Midlanders hold on and claim the win - equalling their best start to a season after three games since their title-winning campaign in 2015-16.