Both sides come into the seemingly meaningless encounter in poor form, with Wolves losing their last two and United winless in three.
Ahead of the game, VAVEL take a look back at three famous Wolves wins over the Red Devils in the 21st century.
Wolves 1-0 Manchester United, 17 January 2004
Bottom side Wolves dented Manchester United's title hopes with a shock win over Sir Alex Ferguson's side in January 2004.
Wanderers, who had been in the drop zone for 17 of the 20 weeks of the season when United came to Molineux, were dominated by their star-studded visitors for almost the entire first half.
Ruud van Nistelrooy was United's main threat, as the Dutchman sent an overhead kick just over the bar before inexplicably missing from inside the six-yard box minutes before the interval.
Wolves were rejuvenated in the second half and went close as former United midfielder Paul Ince hit the bar before Kenny Miller gave the hosts the lead as he pounced on a loose throw-in, beat Wes Brown and slotted into the corner in front of a delirious North Bank.
The likes of Cristiano Ronaldo, Diego Forlan, Paul Scholes, Roy Keane and van Nistelrooy couldn't find a way past a stubborn Wolves defence, who held out for their first victory against United since 1980.
Wolves 2-1 Manchester United, 5 February 2011
Lightning struck twice for Wolves as they again beat Manchester United in a bottom versus top clash in February 2011.
United, who had not suffered a league defeat for 10 months, took the lead after just three minutes as Nani struck a low shot past Wayne Hennessey after cutting inside from the right.
Their lead lasted just seven minutes. Matt Jarvis and new boy Adam Hammill combined in a short corner routine before the former crossed for George Elokobi to head home past Edwin van der Sar.
Five minutes before the interval, Mick McCarthy's side took the lead. Nenad Milijas' free-kick was met by both Elokobi and Kevin Doyle in front of goal, with the ball touching the Irishman last and leaving van der Sar helpless.
Despite a second-half dominated by the visitors and five agonising minutes of injury time, Wolves held on to destroy United's hopes of an unbeaten season in the unlikeliest of circumstances.
Wolves 2-1 Manchester United, 16 March 2019
Wolves reached the FA Cup semi-finals for the first time in 21 years as they beat Ole Gunnar Solskjaer's United in front of a bouncing Molineux two years ago.
In a tense first-half Wolves had the best chance as Diogo Jota was set free, but his tame effort was comfortably saved by cup keeper Sergio Romero.
Nuno Espirito Santo's side burst into life in the second half and deservedly took the lead on 70 minutes. Joao Moutinho broke into the box and found Raul Jimenez whose initial efforts were blocked, but the Mexican expertly fired past Romero on the turn to make the majority of the 31,000 inside Molineux dream of a trip down Wembley Way three weeks later.
A trademark Wolves counterattack doubled the lead just six minutes later, as Jota wriggled free of Luke Shaw and blasted the ball past Romero at the near post to cement Wanderers' semi-final berth.
Marcus Rashford's consolation in the last minute of stoppage time couldn't stop the celebrations as Wolves produced one of their finest performances in recent years to reach the last four.