The hosts earned their first Premier League goals and points of the season at Vicarage Road as they beat Watford 2-0 last weekend, while conversely, the Bees suffered their first defeat this campaign as Brighton took three points at the Brentford Community Stadium.
Ahead of the latest encounter between the two sides, VAVEL take a look back at some of the most notable of Brentford's more recent trips to Wolverhampton.
Wolves 2-1 Brentford, 28 December 2014
Kenny Jackett's Wolves picked up a crucial win against play-off chasing rivals Brentford in December 2014.
Wanderers, who had won at Watford just 46 hours earlier, took the lead after seven minutes when Nouha Dicko scored his second goal in as many games, although replays showed the Mali international to be clearly offside.
The hosts' lead was doubled in the second half as Kevin McDonald's close-range effort went in via a combination of David Button and James Tarkowski with the latter credited with the own goal. McDonald was then dismissed on 77 minutes for a second bookable offence following a late tackle in midfield.
Jake Bidwell's cross was deflected into his own net by Danny Batth in the closing stages, but ten-man Wolves held out for an important three points.
Wolves 3-1 Brentford, 24 September 2016
Walter Zenga picked up his fourth and final win in charge of Wolves as they picked up a 3-1 victory over Brentford in September 2016.
After a goalless first half in which Wolves were denied a seemingly stonewall penalty, the hosts took the lead two minutes into the second 45 after a brilliant Helder Costa run ended with Joao Teixeira finishing under Daniel Bentley for his first Wolves goal.
The Portuguese picked up his second just ten minutes later when his free-kick from the left went through everyone and into the net, but Sulley Kaikai's superb strike reduced the deficit back to one midway through the second half.
Another lightning Wolves counter attack saw Ivan Cavaleiro wrap up the three points that would prove to be Zenga's last in the West Midlands, as five winless games on the bounce would see an end to the crazy Italian.
Wolves 3-0 Brentford, 2 January 2018
Championship leaders Wolves comfortably dispatched of mid-table Brentford in their first game of the new year in 2018.
Diogo Jota scored Wolves' third of the evening after a corner caused chaos in the Brentford area, with the Portuguese international poking home just ahead of Ryan Bennett.
With the win Nuno Espirito Santo's side moved 14 points ahead of third-placed Cardiff, and would eventually win the division with 99 points.