The loss against Chelsea was Antonio Conte's first league loss as Spurs boss and he will be hoping his side can regain their form and progress to the fifth round of the cup as he looks to end Tottenham's well documented trophy drought.
Tottenham will be boosted by the return of star Heung-Min Son who recently returned to full training following a muscle injury sustained in the first leg Carabao Cup semi final defeat against Chelsea at Stamford Bridge.
There is another potential return from injury for Spurs, with summer signing Cristian Romero also back in full training, another big boost with the Argentine having only one domestic appearance under Conte so far.
Antonio Conte has said that January signings Dejan Kulusevski and Rodrigo Bentancur are fit and available for tomorrow however it is unlikely they will start, with the Italian saying "To start the game I think is not right because they need to work with the team for a period."
Two players that certainly will not be starting tomorrow are academy products Oliver Skipp and Japhet Tanganga who are suffering from groin and knee injuries respectively and are Tottenham's only injury concerns.
Graham Potter's side came into the winter break with a trio of successive 1-1 draws, with two of them coming against Chelsea and Leicester City.
Captain Lewis Dunk looks likely to make his full return from a knee injury following being on the bench against Leicester in the Seagull's last game before the break according to Brighton and Hove Independent.
Yves Bissouma, Adama Lallana and Shane Duffy are all back in contention for the game while Graham Potter is hopeful to include Moises Caciedo in his matchday squad as he returns on Saturday from playing with Ecuador.
One Centre back that Brighton will be without is Dan Burn following his move to Newcastle United in the winter window. Alexis Mac Allister has been ruled out with COVID, while Enock Mwepu and Jeremy Sarmiento are back in training but will not be in consideration for Saturday.
The south coast club have got through the fourth round of the FA cup in three of their last four attempts, reaching the semi-finals in the 2018/2019 season.
The teams are yet to meet in the league this season due to the originally scheduled game being postponed.
The sides won a game each against each other in the league last season with Brighton winning 1-0 in the most recent encounter.