The Hoops are coming off of a stirring 2-2 draw against Sunderland with goalkeeper Seny Dieng equalizing in the second minute of stoppage time to earn the London outfit a point.
A 1-0 defeat to Swansea City consigned the Tangerines to a second straight defeat with Olivier Ntcham netting the only goal of the match. Blackpool haven't scored in 261 minutes.
QPR were 2-1 winners in this fixture last year with the reverse fixture ending in a 1-1 draw.
Jake Clarke-Salter is expected to be out until September with a hamstring issue that has forced him to miss the last week of training.
Chris Willock and Kenneth Paal missed out against Sunderland, but are expected to return and will likely be on the bench.
Backup goalkeeper Ben Amos will be out until the international break and Taylor Richards will miss two months with a thigh injury.
Jake Beesley and Kevin Stewart both remain sidelined as they continue to recover from stress fractures in the foot.
Queens Park Rangers: Dieng; Hamalainen, Dickie, Dunne, Kakay; Chair, Johansen, Field, Adomah; Roberts, Dykes
Blackpool: Grimshaw; Thompson, Ekpiteta, Williams, Gabriel; Dougall, Carey, Patino; Hamilton, Yates, Bowler
Ilias Chair (Queens Park Rangers)
Began QPR's comeback against Sunderland with a stunning strike from 20 yards away and linked up well with second half substitute Tyler Roberts.
Set up goalkeeper Seny Dieng's improbable equalizer. When Roberts is fully fit, the duo will form a dangerous attacking threat with their pace and ability to create.
Shayne Lavery (Blackpool)
Made a real impact coming off the bench by putting Swansea under pressure and with the Tangerines struggles in front of goal, could be in line to start.
Where is the match being played?
The Kiyan Prince Foundation Stadium will play host to this match.
What time is the match?
Kick-off is scheduled for 8pm BST.
How can I watch the match?
Sky Sports Football will have coverage starting at 7pm.