Brendan Rodgers' side have guaranteed themselves a spot in Europe after their much-needed victory over Sheffield United on Thursday but know that a positive result in North London could be a major boost to determine whether they are playing Champions League or UEFA Europa League football next season.
Jose Mourinho's men, meanwhile, have rediscovered their form of late and are unbeaten in their last four games, including back-to-back victories in their last two games against rivals Arsenal and an away win at Newcastle United on Wednesday as they look to finish in a top six spot.
Spurs striker Harry Kane has been a constant threat over the years for his club and will be their main source of inspiration for goals as he looks to lead his side to victory.
Kane surpassed the 200 goal mark at club level against Newcastle on Wednesday and has enjoyed a rich vein of goalscoring form against this weekend's opponents - with 12 goals in nine games against the Foxes - who know that nullifying the England captain will be no easy task.
Despite being 36, Leicester captain Wes Morgan showed no signs of slowing down as he played a big role in the win over Sheffield United and is likely to feature again this weekend.
Morgan made his first Premier League start for the club since the win over West Ham United in December and with Caglar Soyuncu ruled out for the rest of the season through suspension, he will be vital in the end of season run-in.
Last time out
August's meeting between the two sides saw Leicester come from behind to win 2-1 which included a James Maddison wonder-strike to seal the points for the East Midlanders.
It was Tottenham hitman Kane who struck first in the tie with his fourth Premier League goal of the season after flicking the ball past the on-rushing Kasper Schmeichel to give the away side the lead.
VAR has been controversial to say the very least this season and it played a huge role for both teams as Wilfried Ndidi had his opener ruled out for handball whilst Spurs were denied the chance to double their lead by the slimmest of margins after Serge Aurier's strike was ruled out for an offside against Son Heung-min.
The away side were left frustrated with that decision as only moments later Ricardo Pereira equalised at the other end to turn the game on its head.
Momentum swung in the way of Leicester and their pressure paid off as Maddison picked up the ball from deep and unleashed a powerful shot from 25 yards to beat Paulo Gazzaniga five minutes from time to make sure the three points would be staying at the King Power Stadium.
Dele Alli and Eric Dier are both ruled out for Mourinho's side for the game at the Tottenham Hotspur Stadium through injury and suspension.
Tanguy Ndombele won't feature again this season for Spurs whilst right-back Aurier will play again after playing the full 90 minutes on Wednesday following the tragic news of the death of his brother.
Lucas Moura is also expected to play some part despite concerns over signs of fatigue from the Brazilian.
Brendan Rodgers, meanwhile, has confirmed that Ben Chilwell, Christian Fuchs, and James Maddison and will not feature again this season through injury.
They join Ricardo Pereira on the injury table and will sit out alongside Caglar Soyuncu who serves the second of a three match suspension.
Youngster Luke Thomas enjoyed a stellar start to life as a first-team player after grabbing an assist in Thursday's win and is expected to continue to deputise at the left wing-back role.
Tottenham Hotspur: Lloris; Aurier, Alderweireld, Sanchez, Davies; Winks, Sissoko, Lo Celso; Lucas, Kane, Son.
Leicester City: Schmeichel; Bennett, Evans, Morgan; Justin, Ndidi, Tielemans, Thomas; Perez; Barnes, Vardy.
Mood is high in and around the Tottenham camp after another win in mid-week but the Spurs boss Mourinho is well aware of the difficult task his side face in their final home game of the season.
He said, “It’s fantastic, yes, but I think we all know what is waiting for us."
"We are playing against one of the best teams in the league, a team that is fighting to play Champions League. So, we know what is waiting for us - a very difficult match.”
“It’s a big game. Since day one, they are in this position. They started the season very, very well and managed to be always there - third, fourth, third, fourth, third, fourth."
"They still are, and I’m pretty sure that in the remaining two matches they are not going to want to lose what was theirs for the whole season, so yes, a big match.”
Brendan Rodgers meanwhile is happy that his side has achieved their goal of European football, but has now challenged his side to go one step better.
Rodgers said, "We can now give everything and play with freedom."
"Our target at the beginning of the season was to get Leicester City back into Europe, and for the players to do that with two games to go is superb."
"We have the opportunity to achieve something more. If we keep the standard, we’ll know we’ve got as good a chance as anybody.”