Casey Stoney's side will look to get back to winning ways at home against a Birmingham side who have won three of their last six Women's Super League games, keeping four clean sheets in the process.
The Brummies' last fixture against Everton was postponed due to a waterlogged pitch, with their only other game in 2021 coming in the 0-0 draw with Brighton.
The Red Devils' new signing Maria Thorisdottir will be in contention for her debut following a permanent switch from title rivals Chelsea. Abbie McManus has headed out of the door with a loan move to Tottenham.
Birmingham will be without Rachel Corsie after she returned to the United States to Kansas City for the upcoming NWSL season. However, they can call upon new recruits Emily Murphy and Ruesha Littlejohn, who both impressed on their debuts against Brighton.
The Blues however are short on numbers for this weekend.
"We might have 15 for the weekend. This group keep working hard and we are always ready not matter how many we have got," City Head coach Carla Ward said.
United starlet Lauren James could be in the reckoning for a starting place after her positive impact from the bench against Chelsea in their most recent game.
Ones to watch
Lauren James is the one to watch for Manchester United in this game. Her technical ability is a level above most in the women's game and her superb curling effort against Chelsea is sure to have earned her a start in this one. She is an exciting talent and someone who could put this game past Birmingham.
For the Blues Claudia Walker is the one to watch. She has led the line superbly well in a generally low scoring Birmingham side, scoring five goals so far this season. In a game where it is unclear who will be part of a stripped bare squad, if she is available, she will have a hard go of it but, given the service is there, she is bound to finish a chance.
The only previous fixture between the pair in the WSL was a 5-2 victory for United away from home in September 2020. Kirsty Hanson scored a brace, alongside an assist to breeze past the Midlands outfit.
How to watch
Australia - Optus Sport
For the rest of the world, including the United Kingdom, the game will be available on FA Player.