Currently in second place in the table, Thomas Tuchel will hope his side can continue to fight around the top of the league, particularly with a huge game against Tottenham Hotspur the following weekend.
That said, this is by far Dean Smith's side's toughest test yet, so how they cope against such a high quality opposition will be exciting to witness.
Tuchel spoke to the media and said: 'Unfortunately we have two players out: N'Golo Kante and Christian Pulisic. N'Golo got injured against Liverpool and still suffers a little bit. For Christian, he came back [...] on crutches. He had an ankle injury with about 10 days out.'
Losing N'Golo Kante is never good for a coach, though the backup is certainly there, especially with the new signing of Saul Niguez, and Christian Pulisic's replacements are not short in number either, with a plethora of players available.
Also out will be Thiago Silva, due to a five-day football suspension, and Reece James, as a result of his red card in the previous game before the international hiatus.
During his press conference, Dean Smith told the media: 'We're missing Carney Chukwuemeka, he got injured on England duty, but we've got some healthy individuals coming back, [including] Ollie Watkins, Leon Bailey, Bertrand Traore, Jacob Ramsey and John McGinn.'
The return of such a wide variety of players will be hugely welcome to the Villa boss, and he will hope that they can all, (though Leon Bailey in particular, as will be discussed later), contribute to the team this weekend.
Other absences include Emiliano Buendia and Emiliano Martinez as a result of them quarantining following international duty with their countries.
Mendy; Chalobah, Rudiger, Christensen; Azpilicueta, Saul, Jorginho, Chilwell; Mount, Lukaku, Havertz
Aston Villa (4-1-4-1):
Steer; Cash, Konsa, Mings, Targett; Luiz; Bailey, McGinn, Young, El Ghazi; Ings
With four competitive games under their belts, the Blues look to be in fine form under the management of Tuchel, coming off the back of a Champions League triumph in May.
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They've already picked up a trophy in the form of the Super Cup and followed that up with two strong wins, and then a defensive masterclass against Liverpool two weeks ago, meaning they look to be on something of a roll coming into this fixture.
Dean Smith's side have had a more difficult opening few weeks, despite playing arguably weaker sides than that of the Blues' first fixtures.
Your August 𝐆𝐨𝐚𝐥 𝐨𝐟 𝐭𝐡𝐞 𝐌𝐨𝐧𝐭𝐡! 🤩 pic.twitter.com/gfjn61XEOo— Aston Villa (@AVFCOfficial) September 2, 2021
However, their form has improved since their opening day defeat, and it's worth mentioning their 6-0 victory over Barrow in the EFL Cup, which allowed various youth players to get their chance in the side.
Ones To Watch
After scoring on his debut against Arsenal in a 2-0 win at the Emirates, Romelu Lukaku found his second game back for the Blues a slightly more difficult affair, particularly in the second half.
However, with a somewhat leaky Villa defence on display this weekend, the Belgian will hope to add to his tally quickly and take advantage of absences in the opposition.
He has already shown how he can utilise his extraordinary strength even against the toughest of opponents, but whether he can do so again remains to be seen.
Since signing during this summer's transfer window, Leon Bailey has thus far only played in one game for Villa, that being the opening day defeat to Watford previously mentioned.
Aston Villa (@AVFCOfficial) August 4, 2021
He arrived with much hype after his huge talent was displayed at Bayer Leverkusen, at which he scored 39 goals and also amassed 26 assists in 156 appearances for the German side.
Unfortunately, he hasn't had much of a chance to replicate that form with his new club due to a minor injury, but watch out for him in this weekend's game.
Previous Five Meetings
In recent history, this fixture has been relatively one-sided, in Chelsea's favour, but one result in particular stands out as an exception to that trend.
Goals came from a certain Ruben Loftus-Cheek, an Alexandre Pato debut penalty, as well as a brace from Spaniard Pedro, consigning their opponents to eventual relegation a few weeks later.
The next meeting between the two teams didn't come until December 2019, when Dean Smith and his side were promoted to the top flight once again, though this wasn't a fixture to remember for them.
Chelsea FC (@ChelseaFC) September 5, 2021
Following the lockdown in the UK, the first fixture for Chelsea in a strange empty stadium world, set to become all too familiar, was against Villa, in which they again were victorious by two goals to nil.
It saw the start of Christian Pulisic's purple patch in the summer of 2020, as he netted the equaliser before just two minutes later the ever-prolific Olivier Giroud put the Blues in front, where they then remained until the full time whistle.
Things started averting from the usual pattern a few months later however, when in late December 2020 the teams couldn't be separated at Stamford Bridge.
In truth, it was a game that reflected much of Frank Lampard's final few weeks in charge - drab, dry and in need of overhaul - with a 1-1 draw being just one of multiple results that led him to the sack.
Finally, in the most recent meeting between the two, it was Aston Villa who came out on top, during a final day clash which, despite the result, was a positive one for Thomas Tuchel's Blues in the end.
The 2-1 loss could've spelt trouble in terms of Top Four, but as other results went their way, both sides went away happy, albeit for wildly different reasons.
How To Watch
This Premier League clash will be broadcast on Sky Sports in the UK at 5:30pm kick off time and over in the USA the action can be found on NBC.
You can also follow along with live updates from the match right here on VAVEL on our live blog page, from around two hours before the game gets underway.