The Foxes face a rejuvenated Napoli side, with Luciano Spalletti's team fresh from a 2-1 win over Italian giants Juventus in Serie A.
Leicester supporters will be eager to see Rodgers' choice for the starting eleven, with the Scotsman having several options for his midfield and attacking options.
Nigerian forward Kelechi Iheanacho may be selected to play alongside lead striker Jamie Vardy. Iheanacho finished the 2020-21 season as Leicester's top scorer with 19 goals in all competitions and has produced some strong displays from the bench.
£23 million summer signing Patson Daka could also receive a chance to shine on the European stage upfront alongside Vardy or Iheanacho.
Young midfielder Kiernan Dewsbury-Hall could be given his first experience of European football following some impressive performances this season whilst summer signing Boubakary Soumaré may also get the chance to star in midfield if Rodgers chooses to rotate the team.
Defensive woes for Foxes
The main worry for Leicester supporters will certainly be the strength of their defence against an attacking side like Napoli.
Rodgers' back-line has struggled since the Foxes' Premier League opening victory against Wolves, conceding six goals in three games with a 1-0 loss to Man City and a 4-1 thrashing from West Ham marking a poor defensive start to the season.
Being plagued by injuries since pre-season, the Foxes have seen five of their first-team defenders absent due to injuries. Summer signing Jannik Vestergaard made his full debut against Man City despite injury worries, he will likely start alongside Çağlar Söyüncü in the heart of the Leicester defence.
Söyüncü has struggled so far this season with several errors costing his side in domestic and international fixtures. The Turkish centre-back may be able to recapture his form when partnered with 29-year-old Vestergaard, who has a wealth of experience under his belt.
Napoli's biggest threat to Leicester are arguably their attacking wingers Matteo Politano and Lorenzo Insigne. Both men have found the net already this season, with Politano scoring a poachers goal in their victory over Juventus.
Alongside netting the dramatic winner against Juventus, Koulibaly has been an excellent defender for Napoli. His strength and speed have helped him become one of the most reliable defenders in Serie A, making a match-up with the danger of Vardy all the more exciting.