The Hammers have taken 11 points from their six games while the Bees have adapted well to the Premier League, claiming nine points through their first half-dozen contests to sit in ninth place.
Ben Johnson deputized at right-back and could get another start should Coufal or Fredericks be sidelined.
West Ham United: Fabianski; Cresswell, Ogbonna, Zouma, Coufal; Rice, Soucek; Benrahma, Fornals, Bowen; Antonio
Brentford: Raya; Ajer, Jansson, Zanka; Canós, Nørgaard, Janelt, Henry; Mbeumo, Toney, Wissa
Ones to watch
Said Benrahma (West Ham United)
The Algerian scored in the Hammers 2-0 victory over Rapid Wien in the Europa League, but the major storyline is him facing his former club for the first time since departing Brentford, where he found the back of the net 27 times in 83 appearances.
Yoane Wissa (Brentford)
Signed from Ligue 1 outfit Lorient, the Frenchman has netted in consecutive games for the Bees. He can play as a winger, forward or number 10, his pressing abilities fit in perfectly with Thomas Frank's style of play and he is a wonderful compliment to Ivan Toney.
The two sides have never met in a competitive match, but they did face off in a pair of friendlies within the last 13 months as West Ham claimed both matches.
The Hammers were 2-1 victors in August of 2020 with Tomas Soucek scoring the match-winner and they won 1-0 in July as Benrahma found the back of the net in the 66th minute.
There will be no live TV coverage in the United Kingdom, but audio commentary can be heard on West Ham's website whufc.com. Kick-off is set for 14:00.