The Clarets will be looking to reach the Quarter Finals for the first time since the 08/09 season when Owen Coyle's Clarets at the time, reached the Semi Finals before eventually losing out to Wednesday's opponents, Spurs.
It is without question that both teams are likely to make a number of changes with key Premier League games at the weekend.
Ben Mee may also return from testing positive for Covid-19 to gain some match fitness.
Spanish youngster, Bryan Gil, is also expected to start for the visitors in a changed line-up.
Burnley: Hennessey, Roberts, Long, Mee, Pieters, Lennon, Brownhill, Cork, Gudmundsson, Vydra, Rodriguez
Tottenham: Gollini, Tanganga, Sanchez, Rodon, Davies, Alli, Lo Celso, Ndombele, Gil, Bergwijn, Kane
Ones to Watch
Connor Roberts (Burnley): It will certainly be interesting to see how the new Burnley full back plays on his debut. The former Swansea man, will look to get up and down on support Lennon down the right and could excite the Burnley faithful.
Harry Kane (Tottenham): It’s these sort of games that will help Harry Kane to build up his form. A small fact of the matter is that Harry Kane quite enjoys playing Burnley with the England captain scoring 9 in 12 against The Clarets in all competitions.
Many Burnley fans cannot forget the clubs run to the Semi Finals in 08/09 with The Clarets eventually losing to Tottenham in the dying stages at Turf Moor.
Remember Burnley's 2-1 over Spurs in 2019? Well, Burnley will be looking for some of that spirit to put themselves in the hat for the Quarter Finals.
This one could be tighter than people anticipate but neither side will really want extra times with games on Saturday. Tottenham may just edge it but it will be close.
Prediction - Burnley 1-2 Tottenham
How to watch
Unfortunately the game is not being broadcasted in The UK but highlights will be available on the respective club's YouTube channels after the game.