The Citizens will be looking to avenge a 2-0 defeat from the reverse fixture on Matchday 2, whilst Mauricio Pochettino will be hoping to steer his cohort to a first ever victory at the Etihad Stadium.
Jack Grealish also returned from the international break with a minor knock, although he could be in line to return to the squad having sat out of Sunday's 3-0 victory over Everton.
There are no other injury concerns for the hosts, who are expected to recall Gabriel Jesus to the starting eleven, after the Brazilian was an unused substitute in the win over the Toffees.
Manchester City: Ederson, Cancelo, Dias, Stones, Walker; Rodri, Gundogan, Bernardo; Jesus, Mahrez, Foden
Paris Saint Germain: Navas; Hakimi, Marquinhos, Kimpembe, Bernat; Gueye, Verratti, Paredes; Messi, Mbappe, Neymar Jr.
Ones To Watch
The Algerian favourite was the difference the last time the two sides met on the Etihad turf, scoring either side of half-time as Manchester City booked their place in a maiden UEFA Champions League final.
Mahrez has been in and out of Pep Guardiola's Premier League plans this season, but has been an ever present in Europe, starting all four of their group stage fixtures so far.
Few would bet against Mahrez playing a key role tomorrow evening.
Lionel Messi is almost always touted as one to keep an eye on, but even more so tomorrow evening.
The Argentine has struggled to hit the astronomical heights expected of him during his time in Paris thus far, though he did score a sublime winner the last time these two sides met.
Pep Guardiola made no secret of his desire to bring Messi to the Etihad, but a move never materialised, with Messi opting for a move to the French capital instead.
The PSG man has had mixed fortunes at the Etihad during his previous visits, winning on two of his three visits to East Manchester, scoring twice but also missing a last-minute penalty.
The Etihad hasn't been a happy hunting ground for PSG in the past. The French side have lost both of their previous visits to East Manchester, failing to score in either meeting.
PSG did win when the two sides met earlier this season though, with Pochettino overseeing a counter attacking masterclass at the Parc de Princes.
How To Watch
The match will kick-off at 20:00 GMT on Wednesday, November 24th.
UK viewers can watch the match live on BT Sport 2 (HD) or BT Sport Ultimate (4K).