The match is a must-win for both sides, but for very different reasons.
The Tykes head into the contest all too aware that anything less than three points well condemn them to relegation and a campaign in League One next season.
Huddersfield Town know failure to win the contest will likely bring their bid for automatic promotion to a close, with Bournemouth sat four points clear, with two games in hand.
The hosts will be without a a trio of key players, with Sorba Thomas out for the rest of the season after picking up a knee injury in Monday's win over fellow promotion chasing .
and Levi Colwill will also be absent as the pair are dealing with a hamstring and hip injury respectively.
The Tykes will once again be without Michal Helik. The defender has missed the last four league games with an ankle injury and could possibly miss the rest of the season.
Aapo Halme is once again unavailable, having spent almost the entire season out.
Nicholls, Lees, Sarr, Turton, Pipa, Hogg, Russell, O'Brien, Toffolo, Rhodes, Thomas.
Walton, Brittain, Andersen, Kitching, Vita, Gomes, Palmer, Styles, Bassi, Quina, Morris.
Ones to watch
With a lot of the club's firepower unavailable, the Terriers will look to Danel Sinani to pick up the weight-load.
The on-loan Norwich City man has been impressive this season with nine goal involvements in his 37 league games.
His six league goals have the 25-year-old second only to Ward in the club's top scorer rankings.
It has been a poor season for after last year's playoff disappointment, but it could have been much worse if not for .
The 26-year-old is the club's top scorer with seven league goals and if they are to stand any chance of escaping the drop, they will need him firing on all cylinders.
In a team lacking firepower, Morris is incredibly important to 's potential success.
The two sides have faced off twice already this season, with Huddersfield eliminating Barnsley from the with a 1-0 win back in February.
The reverse fixture saw the pair share the points in a 1-1 draw after Morris cancelled out Lewis O'Brien's opener.
Over their last 10 meetings, the sides have won four games apiece, with two draws rounding it out.
How to watch
The game will kick off at 19:45 BST at The John Smith's Stadium in Huddersfield, England on Friday, April 22.
The match will be broadcast on television and fans can watch it on Sky Sports Main Event and Sky Sports Football.