On Fulham's last venture in the top-flight, their hosts did the double over them with a pair of 1-0 victories at home in October of 2020 and in London in April of 2021.
The hosts look to be shorthanded as several key players are set to miss out with Raul Jimenez headlining that group, as last season's top scorer has a knee injury.
Manor Solomon, who joined the Cottagers from Ukrainian side Shakhtar Donetsk, has been ruled out as the Israeli is suffering from a knee injury.
Nathan Chalobah is set to return from an injury suffered in a match played behind closed doors on July 31.
Goncalo Guedes (Wolverhampton Wanderers)
He instantly becomes Wolves' most important player with the absence of Jimenez and his dribbling ability, which is enhanced by being able to position himself in the right spot, is among his many strengths.
How he develops chemistry with the midfield, in particular Podence, will also play a key role in the success the club will have.
Aleksandar Mitrovic (Fulham)
He picked up where he left off last year, when he smashed the Championship goal-scoring record with 43, by netting both of the Cottagers' goals against Liverpool.
While the Serb has scored for fun in the second tier, he only found the back of the net three times during Fulham's last top-flight campaign after scoring 11 times in 2018-19.
Manager Marco Silva mentioned that Mitrovic is "A striker who can add something different. With or without the ball, he is working hard", showing the 28-year old is always looking to add more to his game.
Wolverhampton Wanderers: Sá; Aït-Nouri, Kilman, Collins, Jonny; Neves, Dendoncker; Neto, Gibbs-White, Podence; Guedes
Fulham: Rodák; Robinson, Ream, Adarabioyo, Tete; Palhinha, Reed; Decordova-Reid, Pereira, Kebano; Mitrovic
Where is the game being played?
Molineux, Wolves' home since 1889, will host this fixture.
What time is the match?
Kick-off is set for 15:00 BST.
How can I watch the match?
Due to blackout rules, the match won't be televised or streamed live. Fulham are offering live audio coverage to subscribers of FFCtv.