Everton are hoping to extend their unbeaten run to seven matches when they travel to face Brentford, who are seeking a third successive league win themselves.
The Toffees were pegged back by Man United in a lively 2-2 draw last time out, which saw them move above their opponents into 14th.
Brentford meanwhile, produced an emphatic 4-0 away win over struggling Leicester to secure a third win in four and sit 11th.
That is a stark contrast from the last time both teams met back in November when Everton played out a 0-0 draw with the Bees who ended up a man down.
It saw Thomas Frank's men pick up their first away points of the season, while the Blues extended their winless run to four matches - a third in a row without scoring.
In fixtures between the two overall, Everton are unbeaten in their last five meetings, while Brentford's last victory came during a 3-2 win in May 2022.
Forgetting the history books, Wednesday night's game proves to be an intriguing encounter between two of the Premier League's in-form sides.
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Team news
Brentford
Brentford will be without captain Christian Norgaard, who was withdrawn at half-time in the win over Leicester after suffering from a concussion.
Thomas Frank also confirmed that several first-teamers remain sidelined including Mathias Jensen, Igor Thiago, Josh Dasliva, Sepp van den Berg, Aaron Hickey, Rico Henry and Gustavo Nunes for Wednesday's fixture.
Everton
David Moyes meanwhile has received a boost with the news that Jesper Lindstrom is available following his early second-half substitution against Man United with illness.
The Scot also confirmed that Nathan Patterson is not yet ready to return to action, while Dominic Calvert-Lewin, Iliman Ndiaye, Dwight McNeil, Orel Mangala, Seamus Coleman, Armando Broja and Youssef Chermiti all remain out.
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Likely line-ups
Brentford
Flekken; Ajer, Pinnock, Collins; Schade, Janelt, Norgaard, Damsgaard, Lewis-Potter; Mbeumo, Wissa
Everton
Pickford; O'Brien, Tarkowski, Branthwaite, Mykolenko; Lindstrom, Gueye, Alcaraz, Harrison; Doucoure; Beto
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Key players
Brentford - Bryan Mbeumo
Another Premier League season has seen the exploits of Bryan Mbeumo, who has showcased himself again as Brentford's talisman with 15 goals and four assists.
The Cameroon international was integral in the 4-0 win at Leicester, scoring a sensational curling strike before an supplying inch-perfect delivery for Norgaard to make it three as Brentford produced a first-half blitz.
Mbeumo's threat can vary between his ability to drift between wide and central areas to create or score in addition to his aforementioned quality from set-pieces, which Everton need to be wary of.
Everton - Beto
Everton's improvement in recent weeks has been down to their attacking play, which has seen Beto change from peripheral figure to man on fire.
The 27-year-old striker has been brought in from the cold following Calvert-Lewin's injury, having netted five in his last four - a run only bettered by Premier League top scorer Mohamed Salah.
That included a goal in Saturday's 2-2 draw with Man United, where his predatory instincts and aerial prowess were clear to see and could be a big problem for the West London outfit.
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Match details
Where is the game being played?
The match will take place at the Gtech Community Stadium in Brentford, West London.
What time is kick-off?
Kick-off is at 19:30 GMT on Wednesday 26th February.
How can I watch?
The game will be televised live on TNT Sports.
