After Thursday night's 2-1 defeat away to Belgium, Wales must win on Sunday in order to avoid relegation from UEFA Nations League Group A.
Rob Page's side have picked up just one point from their five matches in Group A4, drawing 1-1 with Belgium in June.
Defeat for Wales would see them return to Group B after just one campaign at the top level.
Poland head into Sunday's clash three points ahead of Wales, although they do have a significantly worse goal difference.
A 2-0 home defeat at the hands of the Netherlands on Thursday night means Poland's future is still uncertain, needing a point to survive relegation.
Czeslaw Michniewicz's side ran out 2-1 winners when Wales travelled to Wroclaw in June. Karol Swiderski's late goal was enough for all three points.
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Team News
Gareth Bale was only fit enough to make a substitute appearance in Brussels on Thursday, although manager Page is confident Bale could start on Sunday.
Page has said that Wales' key man has trained "really well" and has "put himself into a position where he could potentially start."
With the World Cup just two months away, it will be interesting to see if Page does risk playing Bale for the sake of Nations League survival.
After picking up yellow cards in their previous game, Ethan Ampadu and Chris Mepham will both miss Sunday's match through suspension.
Ben Cabango could be recalled to fill in at centre half with Joe Morrell playing in midfield.
Czeslaw Michniewicz is expected to make little to no changes to his side that lost at home on Thursday night.
Szymon Zurkowski is available for selection again after missing Poland's previous game through suspension.
Robert Lewandowski has no injury concerns and is expected to lead the Polish attack in Cardiff.
Aston Villa's Matty Cash has missed out on the squad after sustaining an injury against Manchester City earlier this month.
Jan Bednarek and Mateusz Klich are the only two current Premier League players in Michniewicz's squad.
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Likely Line-ups
Hennessey; Cabango, Rodon, Norrington-Davies; Roberts, Morrell, Smith, Williams; Bale, Moore, Johnson (3-4-3)
Szczesny; Bednarek, Glik, Kiwior; Frankowski, Krychowiak, Linetty, Zalewski; Szymanski, Zielinski; Lewandowski (3-4-2-1)
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Key Players
Naming Bale as key player is a bold shout considering his recent injury concerns, but he cannot be counted out.
Bale is Mr Reliable for Wales, always putting in big performances when it matters most.
His free-kick in Wales' 1-0 win over Ukraine was the goal that sent his nation to the World Cup in Qatar.
The Qatar World Cup will be Wales' first since 1958, ending a long wait for the nation.
Their opening group game against the United States is just 58 days away. Risking Bale's fitness in the hope of Nations League survival would be a huge call for Page to make, but one that could reap enormous benefits for his side.
With 40 goals in 107 games in a Wales shirt, Bale sits comfortably as his country's all time leading goal scorer.
Lewandowski has been one of Europe's elite strikers for the past decade. 312 Bundesliga goals in 12 years puts the Polish striker second in the league's history, only behind Gerd Muller.
His electric start to life in Barcelona has come as no surprise, scoring 11 in eight games for La Blaugrana.
Despite his stellar club form, Lewandowski has scored just one goal in this year's Nations League campaign, scoring the opener in a 6-1 defeat against Belgium.
Lewandowski's presence in attack will still strike fear into Welsh hearts.
With Poland needing one point to confirm safety, a goal from Lewandowski will go a long way to helping his country.
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Match Details
Where is the game being played?
The game will take place at the Cardiff City Stadium,, Cardiff.
What time is kick-off?
Kick-off is at 7:45pm GMT, Sunday 25th September.
How can I watch?
UK viewers can watch the game live on S4C and Premier Sports.