Burnley face Brighton and Hove Albion, with both teams in need of three points to add distance between themselves and the bottom three.
The Clarets fell to a second consecutive defeat in midweek, losing once again to Manchester City, while Brighton picked three vital and memorable points at Liverpool, something their opponents this weekend did a couple of weeks ago.
Heading into the game, Burnley have a comfortable eight-point advantage over 18th placed Fulham, whereas The Seagulls, sitting in 15th, boast a 10 point lead above the relegation zone.
Chris Wood and Ashley Barnes face a race to be fit for the home side, having both missed the City defeat, as Matej Vydra and Jay Rodriguez took their places.
Charlie Taylor and Josh Brownhill also missed the defeat at Turf Moor, but they will also be assessed ahead of kick-off.
It is unlikely any of the four names mentioned will be fit enough to start, so Sean Dyche could name an unchanged team.
Graham Potter will be without Solly March who was withdrawn from the Liverpool game with an injury his manager said “does not look good”.
Joel Veltman could return to starting line-up with Tariq Lamptey still missing, while Danny Welbeck and Alexis Mac Allister potentially making the bench.
Pope; Lowton, Tarkowski, Mee, Pieters; Gudmundsson, Westwood, Cork, McNeil; Vydra, Rodriguez
Brighton and Hove Albion
Sanchez; White, Webster, Dunk; Veltman, Alzate, Bissouma, Gross, Burn; Trossard, Maupay.
Burnley have the lowest number of goals this season in the Premier League, only hitting the net 13 times.
They have a better defensive record than Brighton, though, conceding one less goal than their opponents (28).
Brighton are unbeaten in their last four games, only losing once in their last six – a 1-0 defeat to Manchester City.
Burnley, on the other hand, have just two wins in their last six, beating Aston Villa and Liverpool.
Ben Mee is The Clarets second highest scorer with two goals this season, level with Barnes.
Likewise, Lewis Dunk has two goals this season, making him his side’s joint second highest scorer as well.
Both teams have seven clean sheets.
Both teams have won just four of their last 15 meetings, with seven draws between the sides since 2006.
Brighton and Hove Albion 0-0 Burnley
The score line says it all for the last time the two sides met.
Nick Pope made a couple of good saves, once to deny Danny Welbeck making his first Brighton start.
Matt Lowton came the closest for the visitors, his deep cross nearly looping over Mat Ryan but hit the crossbar instead.
It was Brighton’s 12th 0-0 draw since they won promotion to the Premier League, with Burnley picking up their 11th stalemate in that time.
The hosts stayed in 16th place after the draw, Burnley moved up from the bottom of the table momentarily, onto just two points.
Burnley vs Brighton and Hove Albion is a 3pm GMT kick-off, live on Sky Sports Premier League.