Dominic Calvert-Lewin fired home with virtually the last kick off the game to earn the Toffees a dramatic point and leave United wondering what could have been.
Paul Pogba was withdrawn from the game against Everton with a thigh-muscle injury and will be forced to sit this one out as Solskjaer believes he will be absent for a few weeks.
The team news is more positive for West Ham who will be grateful to see star player Tomas Soucek's red card overturned following his dismissal against Fulham. However, Jesse Lingard is ineligible for selection against his parent club having recently joined the Hammers on loan from the Reds.
Man United: Henderson, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, McTominay, Greenwood, Fernandes, Rashford, Cavani.
West Ham: Fabianski, Coufal, Dawson, Ogbonna, Creswell, Rice, Soucek, Bowen, Benrahma, Fornals, Antonio.
Ones to watch
Mason Greenwood has not displayed the scintillating form he produced has season in the red shirt, but he is starting to show glimpses of just how special he is again as of late. The youngster will be disappointed not to have been on the scoresheet more often this season and will be out to impress week in and week out in order to nail down a more regular starting place.
A goal last time out in the cup against Liverpool along with the fact that he fired home in his last match against West Ham will bode well for Greenwood in this game and it would not be surprising to see him amongst the goals in thiss game.
As for West Ham, Pablo Fornals could cause problems for his opponents as he looks to force his way back into the side. The Spaniard has impressed this season and has perhaps been unlucky to be dropped in the past two games as Lingard was given the nod.
With Lingard unavailable for this game, Fornals will be looking to seize the opportunity as he aims to regain his place in David Moyes' team.
Head to head
It is West Ham who have enjoyed the better form over the past five games having picked three wins, a draw and a defeat while Man United have only managed two wins, two draws and a defeat.
Like the two sides form as of late, the direct head to head has been a mixed bag with two wins each and a draw over the last five meetings.
However, the Red Devils may be encouraged by the last time the two clubs played each other in the FA Cup. Following a 1-1 at Old Trafford in the quarter-finals back in 2016, Louis Van Gaal led his side to a 2-1 victory in the replay en route to lifting the trophy.
Manchester United 2-1 West Ham
Where to watch on TV
The match will kick off at 7:30 PM live on BBC One.