It will be the first time in 52 years since the Foxes last reached the final of the competition where they are the only side to have reached the final more than once and not lift the trophy.
Meanwhile, Chelsea will look to go one better this season after they finished runners-up last year - losing to Arsenal whilst also looking to secure their first piece of silverware under manager Thomas Tuchel.
Wembley Stadium will also welcome fans through its door for Saturday's game, with up to 22,500 spectators attending the game as part of the government's pilot test scheme.
Brendan Rodgers is hopeful that defender Jonny Evans will be available for selection. The Northern Irishman has missed Leicester's last two games through injury but has been seen in training this week and there is growing optimism that he will feature.
Ricardo Pereira and James Maddison will also be fit for contention for the trip to the Capital. Pereira was an unused substitute in Tuesday's win at Manchester United whilst Maddison came on for the last 30 minutes.
Chelsea will be sweating on the fitness of former Leicester man N'Golo Kante who has complained of trouble with his achilles.
He joins Mateo Kovacic who Tuchel has also confirmed is a doubt but there is hope that Andreas Christensen will be fit to return as well as Antonio Rudiger who was rested midweek to prevent overload.
Kepa Arrizabalaga has started in cup competitions for the Blues this season and looks set to continue that on Saturday.
Chelsea: Kepa; Azpilicueta, Silva, Rudiger; James, Jorginho, Kante, Alonso; Ziyech, Mount, Werner.
Leicester City: Schmeichel; Fofana, Evans, Soyuncu; Pereira, Tielemans, Ndidi, Castagne; Perez; Vardy, Iheanacho.
The earlier season meeting between the two sides saw Leicester convincingly beat Chelsea 2-0, which proved to be one of Frank Lampard's last games in charge of the club.
First-half goals from Wilfred Ndidi and Maddison made sure of the points for the Foxes however this time around will be a different proposition with a rejuvenated Chelsea side one of the most in-form in Europe.
Ones to watch
Mason Mount - Chelsea
Mason Mount has been one of the stars in the Premier League this season and has established himself as Chelsea's star player.
In just his second full season in the top-flight, Mount has 11 goals and assist contributions to his name and he will look to continue his impressive run in-front of goal to guide his side to a ninth FA Cup win.
Wilfred Ndidi - Leicester City
Lauded for his efforts in Tuesday's win in the North West, the Nigerian is an instrumental member in the cog of Leicester City.
Regularly topping the charts for tackles and interceptions, the 24-year-old is the barrier in front of the back three and could be vital if the Foxes are to secure a winner's medal come the full-time whistle.
After starting goalkeeper Kepa in the midweek defeat to Arsenal on Wednesday, Chelsea boss Thomas Tuchel has reaffirmed his trust for the Spaniard by confirming he will start.
"He [Kepa] starts the FA Cup final, and we thought it was a good idea to give him the game before. We trust him and he deserves it.
“That is the basis of why we put him in the line-up. He deserves it. He is so close and good in training.
“We wanted to give him some minutes and take both games together. It was an unlucky night for him as well."
Leicester boss Rodgers meanwhile spoke ahead of leading his side out in their first cup final during his managerial reign and admitted that the Foxes want to win the trophy in honour of their late owner Vichai Srivaddhanaprabha.
"I'd love to win it for Khun Vichai and his family," Rodgers said. "His spirit and presence will be there with us on the day.
"Having Top over this week has really magnified one of the reasons I came here. It was because of them and the cause Leicester City has.
"Of course, I'd love to do it for the players, I'd love to do it for the supporters, but if I had to pin one it would be for Top and his family. That would be truly special."
How to watch
The FA Cup final will be available to watch on both BBC One and BT Sport 1 and 1HD, with coverage on the BBC beginning at 16:15pm and at 15:00pm on BT Sport.
Alternatively, you can keep up to date with live text updates on the VAVEL website and Leicester VAVEL Twitter page.