The Reds have lost their last two games - against Liverpool (4-2) and Leicester City (2-1). They'll be wanting to bounce back and finish of the season strong, hopefully maintaining their position in second place.
Fulham were relegated by Burnley last week after losing 2-0 to The Clarets, they now don't have anything to play for other than pride. Manager Scott Parker knows that he has got a big re-build mission on for next season and could well look at giving minutes to those who he is expecting to still be at the club in the Championship next campaign.
With the Europa League final in just over a weeks time, Ole Gunnar Solskjær could rest players in United's final game of the season against Wolves. Therefore, we could see quite a strong squad out against Fulham.
As for the London side, Tom Cairney and Terence Kongolo remain unavailable for selection through injury, but Mario Lemina should be back in the matchday squad, having been ineligible to face parent club Southampton on Saturday. Antonee Robinson is said to be 'touch and go' heading into Tuesday's game, it looks like he won't be involved against United.
26-year-old Aleksandar Mitrović will be hoping to get some game time. He's only managed to get three goals in the league this season. Should he stay at the club, he could be heavily involved and crucial to Parker in the Championship next season.
Manchester United: Henderson; Wan-Bissaka, Lindelof, Tuanzebe, Shaw; McTominay, Pogba; Rashford, Fernandes, Greenwood; Cavani
Fulham: Areola; Tete, Andersen, Adarabioyo, Aina; Lemina, Reed; Lookman, Reid, Carvalho; Mitrovic
Ones to watch
Manchester United - Mason Greenwood
19-year-old Mason Greenwood has been in great form recently for United. He's scored six goals in his last seven Premier League games. With the Euro's coming up shortly, the young English forward is giving England manager Gareth Southgate plenty to think about.
The attacker seems to be developing well and is learning a lot from veteran team mate and striker Edinson Cavani. Greenwood can play anywhere across the front three - he seems to feature mainly on the right hand side where he can then cut in on his left foot.
However, recently Greenwood has featured up front on his own and he has not disappointed. It seems like he can find space where there is none and it appears that he can finish on either foot causing defenders to have nightmares.
Fulham - Ademola Lookman
Ademola Lookman has been one of Fulham's better players this season. He's scored four and assisted four in this years league campaign.
One of his four goals came against United in the reverse fixture this season. Even though Solskjær's men were the winners on the day (2-1), Lookman opened the scoring in the game after just five minutes.
The winger who is on loan from RB Leipzig will be wanting to add to his goal/assist tally before returning to the German club. And with the club having nothing to play for, Lookman could be given a lot of freedom to express himself at Old Trafford on Tuesday night.
How to watch and kick off time
The game will kick off on Tuesday evening (18/05/2021) at 18:00 BST. It will be broadcasted live on Sky Sports Premier League and Sky Sports Main Event.