However, the Foxes have suffered from an injury-plagued season with many of their top players absent for the fixture against Forest.
Leicester manager Brendan Rodgers will hope that his side will be able to reproduce a similar performance to their third-round victory over fellow Premier League side Watford, the Foxes were victorious in an impressive 4-1 routing.
Fortunately for Rodgers, he will have two of his first-team players return from the African Cup of Nations in time for the clash with Forest. Wilfred Ndidi and forward Kelechi Iheanacho rejoin the squad from their duty with Nigeria.
Full-backs Ricardo Pereira and Timothy Castagne will also miss the clash as they too remain on the treatment table. Main striker Jamie Vardy is still unavailable following his hamstring injury suffered against Liverpool in December.
Young full-backs Luke Thomas and James Justin will likely complete the four-man defence with Tielemans and Kiernan Dewsbury-Hall sitting in midfield. There could be a start for Ndidi, however, Rodgers may not want to risk using the returning midfielder sooner than necessary.
Rodgers will have the option of using either Iheanacho or the in-form Patson Daka upfront with Vardy still sidelined. Daka will likely start as the lone striker, having scored in the last fixture against Brighton in the Premier League.
Leicester City XI: Schmeichel, Thomas, Söyüncü, Amartey, Justin, Dewsbury-Hall, Tielemans, Maddison, Barnes, Lookman, Daka
Having won one of their last eight meetings with rivals Leicester, Forest fans will be eager to cause an upset over the current FA Cup holders.
The Reds head into this fixture off the back of a busy January transfer window, having signed five new additions all available for the clash with Leicester.
Goalkeeper Brice Samba will likely remain in goal behind a back-three of Joe Worrall, Steve Cook, and Scott McKenna.
Top striker Grabban suffered a potential ankle injury in their last fixture against Cardiff, leaving Forest without their main goal threat for the meeting with the Foxes. New signings Davis and Surridge may lead the line for Cooper's side with Grabban sidelined.
Nottingham Forest XI: Samba, Worrall, Cook, McKenna, Spence, Colback, Yates, Zinckernagel, Garner, Davis, Surridge