Leicester head into the clash as strong favourites, with Championship side Millwall having picked up just one win in eight league games so far this season.
Despite the rocky start to the campaign, Gary Rowett's side will certainly be confident that they can cause an upset if given the chance. The Lions have scored in eight of their last nine matches which could be a worrying sign for the recently weakened Leicester defence.
The Foxes' may be without experienced defender Jonny Evans, who continues to struggle with his reoccurring foot injury. The Northern Irishman was substituted at half-time in the club's Europa League 2-2 draw with Napoli and is a doubt for the clash with Millwall.
Rodgers will also be without defenders James Justin and Wesley Fofana who remain absent due to long-term injuries.
Hosts Millwall will likely be boosted by the return of defender Shaun Hutchinson who recently returned to training following a thigh muscle injury.
Ones to Watch
With the Carabao Cup offering Rodgers a chance to rotate his squad, there could be chances to start for several of the Scotsman's players.
Already developing a solid reputation, there could be a start for promising academy graduate Kiernan Dewsbury-Hall whose box-to-box style of play has made him popular amongst Leicester supporters.
The 23-year-old has produced some impressive performances from midfield, potentially earning him his second start ever against Millwall.
Able to pick out inch-perfect passes and break down opposition attacks, the Englishman will be aiming to break into the Leicester first-team with a strong display against the Lions.
Having made three impressive performances from the bench this season, 23-year-old Ademola Lookman will likely receive his first start for Leicester this Wednesday.
The pacey winger joined the Foxes on loan from RB Leipzig this summer and could fill the wide void that Leicester have been attempting to correct over the past few seasons.
Gifted with speed and technique on the ball, Lookman could be one of Leicester's main dangermen against Rowett's side as the Foxes aim to get back to winning ways.
Millwall's main threat in attack will certainly be striker Matt Smith, with the 32-year-old possessing a solid reputation as a dangerous and effective target-man.
At 6ft 6inches tall, the forward will be at his most lethal in the air, battling with Leicester's defenders Caglar Soyuncu and Jannik Vestergaard will be the key battles of this game and will likely be an entertaining affair.
Leicester City: Schmeichel, Thomas, Soyuncu, Vestergaard, Pereira, Lookman, Dewsbury-Hall, Soumare, Barnes, Daka, Vardy.
Millwall: Long, Pearce, Wallace, Cooper, Leonard, Kieftenbeld, Mitchell, Malone, Wallace, Bennett, Smith.
When does Millwall vs Leicester City kick-off?
The match will take place on Wednesday, September 22, with kick-off at 7.45 pm.
Where can I watch the highlights of the game?
As this fixture was not selected for broadcast by rights holders Sky Sports, the highlights of the game will be shown on Carabao Cup On Quest at 10.30 pm on Wednesday.