The Clarets know that anything other than a victory would put their six year Premier League stay in danger whereas victory could provide a huge confidence boost.
Neither side will want to lose which could make for a feisty encounter in East Lancashire.
Matej Vydra could also be back in contention as he played for the U23's after recovering from a hernia operation and a dislocated elbow.
Burnley will also be without Johann Berg Gudmundsson who is out with a calf injury.
Donny Van de Beek will also be out after he injured himself in the warm up at the London Stadium at the weekend.
The Toffees are boosted by the return of captain Seamus Coleman after the Irishman returns from illness.
The blue side of Merseyside will also be without Allan who is still suspended along with an endless list of injury concerns that faces the Everton boss.
Ones to Watch
If there was ever a time for one of Burnley's key men to step up, it's certainly Maxwel Cornet's time. The Ivorian looked bright off the bench in a lacklustre performance against Manchester City and Sean Dyche will be hoping his freshness and trickery will cause Seamus Coleman problems.
The Brazilian has caused Burnley many problems before. He has certainly been Everton's standout man this season and if Everton want to pick up an away victory at Turf Moor, the former Watford man will have to be on top form alongside Dominic Calvert-Lewin.
Burnley: Pope, Roberts, Collins, Tarkowski, Taylor, Lennon, Westwood, Brownhill, McNeil, Cornet, Weghorst (4-4-2)
Everton: Pickford, Coleman, Holgate, Godfrey, Kenny, Doucoure, Iwobi, Gordon, Gray, Calvert-Lewin, Richarlison (4-3-3)
It's no question that both of these sides have had a very difficult campaign and will want to do all they can to avoid dropping into the Championship.
Everton won the reverse fixture 3-1 back in September when they were near the top of the table at the time under Rafa Benitez, but the tables have turned and Everton are bang in trouble. Goals from Andros Townsend, Michael Keane and Demarai Gray sealed it for Everton on the night.
A team who haven't scored since February against a team who can't win away is a very difficult one to call. A draw will do neither side any good but they will naturally be desperate to avoid a crushing defeat.
Prediction - Burnley 1-1 Everton
How to watch
The game is being broadcast live in the UK with the game being shown live on Sky Sports Premier League. Kick-off for the game is 19:30 BST with pre-match build up starting an hour prior.