The Reds are 3-1 up on aggregate after their trip to the Estádio da Luz last week.
Ibrahima Konate netted his first goal in Liverpool red after climbing highest to head home a delightful Andy Robertson corner.
Sadio Mane doubled Liverpool’s lead on the night as he had the joyous task of tapping home following an exquisite, unselfish header from Luis Diaz who was picked out by a trademark cross-field pass by Trent Alexander-Arnold.
It wasn’t all plain sailing for Klopp’s Men as Darwin Nunez justified why numerous big clubs are searching for his signature. The Uruguayan capitalised on a misjudgement by Konate to fire passed Alisson.
Luis Diaz gave Liverpool some breathing space moments from time as he took the ball round Odysseas Vlachodimos and finish into an empty night. A fitting way for the Colombian to return to Portugal, and to the home of his former club’s rivals.
Klopp will know Liverpool have to remain focused and can’t afford to slip up, with the first leg illustrating that Benfica can dominate large spells of the game and ask Liverpool’s defence questions.
Liverpool come into the game off the back of playing out a 2-2 draw with Manchester City at the Etihad Stadium on Sunday and are set to meet them again on Saturday for the Semi-Final of the FA Cup at Wembley.
A win on Wednesday would be the perfect dress rehearsal for Klopp and his players before they travel to the capital, in the hope of taking one step closer to more domestic success this season.
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Klopp had a full complement to pick from ahead of Liverpool’s crunch match against Manchester City on Sunday, but it’s likely there will be rotation tonight depending on how much the Man City game has influenced the fitness of the Reds.
Klopp said: "The last game will have an influence on tomorrow. Nobody is injured as far as I know, but we need to have a look at who is fresh enough for this game.”
A likely alteration is to bring Konate back into the fold and bring Luis Diaz back into the starting eleven. Two players that were benched at the weekend but enjoyed strong performances last week in Lisbon.
The last four beckons for the Reds
The Reds will be hoping to get through this second leg with no major scares to meet Villareal in the final four.
Unai Emery’s side defied all odds to eliminate European Giants Bayern Munich from the competition courtesy of a late goal by Samuel Chukwueze at the Allianz Arena on Tuesday.
If the Reds are to reach this stage, it’ll be the twentieth time Liverpool have achieved this in their history.
One to watch: Darwin Nunez
Benfica will give it all they have to set up a semi-final tie between themselves and Villareal.
If the Portuguese side were to do anything at Anfield, you’d be fooled not to expect Darwin Nunez to be heavily involved.
The Uruguayan is enjoying a fine goalscoring season and is certainly deserving of the interest large clubs have for him.
He had minimal chances in the first leg, but he certainly took his goal well. The best strikers only need one chance, and didn’t Nunez take it.
Jurgen Klopp was full of praise for the 22-year-old striker in his pre match press conference on Tuesday.
Klopp said: "An extremely good looking boy eh?! He was calm for the finish. He is good, really good. If he stays healthy, he has a big career ahead of him."
How to watch
The game will be broadcasted on BT Sport 3.
Kick off: 8pm