The Hatters are newly promoted to League Two and are back playing in the Carabao Cup this season for the first time since 2010.
Dave Challinor’s men beat fellow fourth tier side Harrogate Town 1-0 in the last round, with a Connor Jennings penalty winning the game.
Their return to the EFL has not been ideal to date, with one win and four losses from their opening five games.
Leicester City are strong favourites for this match-up, but Brendan Rodgers’ side have started the Premier League season poorly with just one point from their first three games.
The Foxes have won this cup three times, in 1964, 1997 and 2000.
They reached the quarter final last season, but were beaten 5-4 on penalties after a 3-3 draw to Liverpool.
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Team news
Stockport
Macauley Southam-Hales is back from suspension and available to play against the Foxes.
Leicester
Centre-back Wesley Fofana is unlikely to play a part as his Chelsea transfer saga continues.
Ryan Bertrand remains sidelined as he continues his recovery from a knee injury picked up in pre-season.
Long-term absentee Ricardo Pereira is unlikely to feature for his side until early 2023 after suffering a ruptured achilles in the Foxes' final pre-season fixture against Sevilla in August.
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Likely lineups
Stockport
Jaros; Lewis, Horsfall, Johnson; Southam-Hales, Croasdale, Camps, Kitching; Sarcevic, Crankshaw; Madden
Leicester
Iversen; Castagne, Soyuncu, Amartey, Thomas; Mendy; Albrighton, Tielemans, Praet, Barnes; Daka.
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Ones to watch
Paddy Madden
32 year-old Madden is somewhat of a Football League stalwart nowadays, with 110 goals across 380 EFL games for five different clubs. He has also represented the Republic of Ireland national side once, in 2013.
After a successful four-season stint at Fleetwood Town in League One, Madden made the surprise move to then National League Stockport in March 2021. His impact was instant, and last season he fired 23 goals in 43 league games to help the Hatters win the league at a canter.
Patson Daka
Also a striker, Daka joined Leicester for £27 million last summer but is still yet to hit real goalscoring form after netting just five league goals in 26 games last season.
He earned his move after two prolific seasons with RB Salzburg saw him net 51 goals in 59 games in the Austrian Bundesliga. The 23 year-old is also a full Zambian international, with nine goals in 31 games for his country.
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Match details
Where is the game being played?
The game is being held at Edgeley Park in Stockport, Greater Manchester.
What time is kick off?
Kick off is at 19:45 BST, on Tuesday, August 23.
How can I watch?
The game will not be televised in the United Kingdom and Ireland.
Highlights will be shown on ITV4 at 10.30pm on Wednesday, August 24.