Barring a six-goal turnover from the Aussies in their final match, the French are secured in top spot.
As for Tunisia, they can still qualify if they win and the other remaining group game finishes in a draw.
Their performances so far have been solid but uneasy on the eye, so a flawless defensive display will be needed if they are to make the knockouts.
Boss Jalel Kadri should be counting on a fully-fit squad for their final group game.
Second-choice goalkeeper Bechir Ben Said is tipped to return to the bench after recovering from injury.
Mohammed Drager was hooked at half-time in their defeat to Australia as they reverted to a four-at-the-back formation instead.
That could free up space for Wajidi Kechrida to start should Kadri opt to keep the same shape.
Former Sunderland winger Wahbi Khazi may be given the chance to start after only making one substitute appearance so far, despite being their second-highest all-time goalscorer.
Goalkeeper Alphonse Areola is a slight doubt with a back strain with the West Ham United man set to miss out on the final Group D match.
Lucas Hernandez's cruciate ligament injury leaves his brother Theo Hernandez as the only recognised left-back in the squad.
Deschamps may opt to rest Theo Hernandez with him definitely going to be needed for the knockouts.
He could also make other changes to the side with Matteo Guendouzi, Kingsley Coman and Youssouf Fofana likely to be considered for starting spots for the final group game.
(3-4-3) Dahmen, Meriah, Talbi, Bronn, Abdi, Laidouni, Skhiri, Kechrida, Msakni, Sliti, Khazri
(4-3-2-1) Lloris, Pavard, Upamecano, Varane, Hernandez, Guendouzi, Fofana, Mbappe, Griezmann, Coman, Giroud
The Tunisian's best player in the defeat to Australia, Msakni will be hoping to replicate an impressive performance in the final group game.
He will need to be at his best when facing the reigning world champions.
Msakni will look to link the stubborn defence with the attack and Kadri should release the shackles on him in order to let him do so.
The Paris Saint-Germain forward reportedly does not want to be rested for their final group game despite them already qualifying for the knockouts.
Mbappe is undoubtedly gunning for the Golden Boot trophy after scoring three goals already in the group stage.
The 23-year-old will be needed if they are to finish the group with a perfect record.
Where is the game being played?
What time is kick-off?
Kick-off is set for 3pm (GMT UK) on Wednesday, November 30.
How can I watch it?
In the UK, the game will be broadcast live on BBC, with audio commentary available on both BBC 5Live and talkSPORT.