Arsenal will face North London rivals Tottenham Hotspur at the Emirates Stadium in a big game for both clubs.
The Gunners will look to get back on track after cup frustration last week, with losses to Newcastle United and Manchester United damaging their hopes of a trophy this season.
They now have the chance to put that disappointment behind them, but it is a tricky fixture against their arch-rivals, who are looking for revenge after their two losses to the Gunners in 2024 still on their minds.
The previous game was won through a Gabriel Magalhaes header in the second half from a corner, with the Gunners resisting pressure from the Spurs attack to get an impressive win,
Arsenal are unbeaten against Tottenham at the Emirates in the League since 2010 and have not lost to them since the end of the 2022 season.
A win for the Gunners would put them 19 points clear of Tottenham, and within as little as three points of league leaders Liverpool, depending on their result away to high-flying Nottingham Forest.
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Team news
Arsenal
The Gunners will be without Brazilian attacker Gabriel Jesus after his serious injury in the FA Cup on the weekend.
The former Manchester City striker was stretchered off in a lot of pain, and there are fears that he has picked up an ACL injury, and could be out for nine months.
The positive news is that the other injury concerns from the United loss do not look serious.
Jorginho and Jurrien Timber had come off with cramp after starting the game which went into extra time, but both look fine to be involved in the midweek fixture.
The same goes for Italian defender Riccardo Calafiori, who missed Sunday's game with a muscle injury, but it has been confirmed by Arsenal manager Mikel Arteta that he will be available.
Bukayo Saka and Ben White remain out for a long period of time, with Ethan Nwaneri and Takehiro Tomiyasu also out but closer to returning.
Tottenham
Tottenham manager Ange Postecoglou will not have either Micky van de Ven or Cristian Romero for a North London Derby for the first time being Spurs manager.
Left-back Destiny Udogie will also be out injured, with Djed Spence looking to continue filling at left-back, while young midfielder Archie Gray predicted to start centre-back again, while Swedish midfielder Lucas Bergvall likely to start in midfield due to his impressive recent form.
Rodrigo Bentancur, Wilson Odobert and Guglielmo Vicario will miss the game.
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Likely line-ups
Raya, Timber, Saliba, Gabriel, Lewis-Skelly, Partey, Rice, Ødegaard, Sterling, Havertz, Martinelli
Kinsky, Porro, Dragusin, Gray, Spence, Bissouma, Bergvill, Maddison, Kulusevski, Solanke, Son
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Key players
Arsenal - Martin Ødegaard
After a few performances which were well below-par of what fans have expected from the Gunners captain, Ødegaard looked back to his best on Sunday, as he created 10 chances and had an expected assists total of two.
The Norwegian midfielder has been key to Arsenal in recent years, with his creativity, leadership and reliability been key aspects to his game which have taken Arsenal to the next level.
While his goals and assists output have decreased this season, he is dropping into deeper areas to help recycle and move the ball through the team, while also pushing on down the right-hand side, which has been harder in recent times without Saka's presence.
If Arsenal are to get anything from this game, he is likely to have a big impact on it.
Tottenham - Dejan Kulusevski
From one Scandinavian playmaker to another, Kulusevski has kept Tottenham ticking this season with his new deeper role.
It is likely that he will start in a more advanced role tomorrow due to injuries, but this will not affect his role in the team.
He has created the second most chances in this team, along with making the most key passes per 90 minutes, with his driving runs at defences causing chaos with his incredible control.
Despite how good this Arsenal defence is, William Saliba and Gabriel will need to be on top form to prevent the Swedish attacker from leaving his mark.
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Match details
Where is the game being played?
The match will be played at Emirates Stadium.
What time is kick-off?
Kick-off is at 20:00 GMT on Wednesday 15 January 2025.
How can I watch?
The game will be live on TNT Sports 1 from 18:30 GMT.
