Three wins and a draw from the four previous home matches, which saw the defending MLS champions score 14 goals, have NYCFC up to sixth in the Eastern Conference standings.
Anton Tinnerholm continues to miss out as he recovers from an Achilles injury suffered last year.
Right-back Steven Moreira has been pronounced fit to start by manager Caleb Porter after missing last week's draw against New England with a hamstring injury.
Star man Lucas Zelarayan is also expected to play, having not started any of Columbus' last three games with inflammation in his right knee, while Kevin Molino still remains out.
There were worries that the game could be delayed, after Columbus' team plane had to be diverted back to Columbus due to dense fog in New York causing the team to leave Saturday morning.
NYCFC: Johnson; Amundsen, Martins, Callens, Gray; Acevedo, Parks; Magno, Rodríguez, Andrade; Héber
Columbus Crew: Room; Santos, Mensah, Williams, Moreira; Morris, Artur, Nagbe; Yeboah, Berry, Igbekeme
Ones to watch
Gabriel Pereira (NYCFC)
He's been a big part of the Boys In Blue undefeated run and is exceptionally godo with his left foot. As he gets used to playing with his new side, this excpetional Brazilian will only become more dangerous.
Pedro Santos (Columbus Crew)
He switched positions, converting from a winger to a full-back on a regular basis after doing so due to injuries within the squad last season and the departure of Milton Valenzuela. Now a full-time left-back, he provides pressure on defense and stretches the team out offensively.
Last July, the Boys In Blue ended a three-match losing streak against the Crew, running out decisive 4-1 winners.
The lead was doubled when Alfredo Morales lofted a ball for Thiago Andrade, the Brazilian chipping goalkeeper Eloy Room.
Andrade turned provider for the hosts' third, nutmegging a defender with his pass and finding Keaton Parks, who tapped home.
Columbus grabbed a consolation goal in second-half stoppage time as Pedro Santos scored from the spot.
Kickoff is set for 7pm Eastern time.