The Reds have won just one of their last five games in all competitions, drawing three in a row, and they face a Southampton side who are looking to complete the league double against them for just the third time in their history.
The Champions were unable to play their last Premier League game against Manchester United due to the United fans protesting inside and outside Old Trafford against the ownership of the club just hours before the match was due to kickoff at 4:30 pm on Sunday.
A free weekend for Liverpool has seen them slip seven points behind the top four, with Chelsea, West Ham United, and Tottenham Hotspur all claiming three points during that weekend.
Liverpool have improved slightly in recent weeks as the Reds are currently on a six-game unbeaten run which is their best run of the campaign.
However, disappointing draws in their last two league matches against Leeds United and Newcastle United have set them back massively. They should have easily won both games with the number of chances they created but they couldn't kill the game off which kind of sums up the Reds' season this year.
Anfield will be the venue for Saturday's game against the Saints, a home once considered a fortress in years gone by.
Liverpool have claimed just six points from their last 30 available in at home in the Premier League; this comes as a shock after they had only dropped 22 points from their previous 66 home games.
Liverpool have struggled against teams in the second half of the table this campaign – winning just two of their 11 matches against sides currently in the bottom seven
However, for the visitors, they are going to Anfield on a poor run of form having lost eight of their last nine away matches in the Premier League. Their previous game was against Leicester City and they came ever so close to victory but Johnny Evans canceled out James-Ward Prowse's opener which left the score level.
Hasenhüttl's men have also failed to score on their last four trips to Anfield, conceding 10 goals in the process.
Jurgen Klopp has no new injury concerns heading into this weekend's game and will be able to welcome Nat Phillips back to the starting lineup. The 24-year-old, who has missed the last two matches with a hamstring problem, is back to play alongside Ozan Kabak in defence.
Defenders Virgil van Dijk (knee), Joe Gomez (knee) and Joel Matip (ankle) remain on the treatment table, while captain Jordan Henderson (groin) and Divock Origi (muscle) are still a few weeks away from a full recovery.
For the visitors, Ralph Hasenhüttl has some positive news going into the game as center-back Jannik Vestergaard's red card has been rescinded after he was shown a straight red card against Leicester City. He is now contention to start alongside Jan Bednarek at the back.
However, for Southampton the treatment room is still well-occupied with Danny Ings (hamstring), Oriol Romeu (ankle), Ryan Bertrand (calf), and William Smallbone (knee) all unavailable for the trip to Anfield while Takumi Minamino is ineligible to face his parent club.
Liverpool predicted Xl:
Alisson; Alexander-Arnold, Phillips, Kabak, Robertson; Thiago, Fabinho, Wijnaldum; Salah, Firmino, Mane
Southampton predicted Xl:
McCarthy; Walker-Peters, Bednarek, Vestergaard, Salisu; Walcott, Diallo, Ward-Prowse, Armstrong; Redmond, Adams
Ones to Watch
Mohammed Salah on the ball is always threatening and provides that spark that Liverpool needs when they are in difficult situations. He provides the outlet for the Reds, especially on the counter-attack
He has been Liverpool's savior this season scoring vital goals at vital times for the team.
The Egyptian, one goal behind Kane, has every reason to believe he can still win what would be his third Premier League Golden Boot, having picked up the award in 2018 and 2019 and Saturday’s game provides the perfect opportunity for Salah to kick-start his quest.
The English man is having his best individual season of his career, currently sitting on eight goals and nine assists in the Premier League.
He holds the Southampton record for the most Premier League free-kick goals and has the league's best free-kick conversion rate since 2003 when Opta started recording stats.
Manchester City manager Pep Guardiola remarked that Ward-Prowse is "the best free-kick taker I have seen in my life"
When Liverpool and Southampton last met on 4th January, the Reds were top of the table with one defeat in 16 games. Danny Ings’ early goal at St Mary’s Stadium set the collapse that is still being felt to this day, with eight defeats in the past 17 matches leaving Liverpool seven points adrift of Champions League qualification.
Liverpool vs Southampton will be shown live on Sky Sports Main Event & Sky Sports Premier League, Coverage starts from 19:30 BST with kick-off at 20:15 BST on Saturday 8th May.