The Clarets ended the Reds' 68-game unbeaten home run when Ashley Barnes stuck away a late penalty in this fixture in 2020/21. It was a result that started a poor run of form for Liverpool at Anfield, so Jürgen Klopp's men will be determined to put that right this time around.
It's only the second game of the Premier League season, but Liverpool fans have a lot of reason to be optimistic. Virgil van Dijk and Joe Gomez are back to full fitness and summer signing Ibrahima Konaté impressed during pre-season. Results may have been hot and cold during preparations for 2021/22, but they hit the ground running when it mattered.
Their opening game of the season was against a kind opponent in Norwich City. Liverpool always score a bag full against the Canaries and last weekend was no different as goals from Diogo Jota, Roberto Firmino and record-breaker Mohammed Salah - the only player to score in five consecutive opening matches - made sure that their season began in the best possible way.
Burnley's home record is going to be key as always in their bid to avoid the drop in what has been dubbed by many as the most competitive Premier League line-up ever, so the 2-1 defeat to Brighton and Hove Albion at Turf Moor in their opening game was not what Sean Dyche's men needed.
That being said, they didn't play too badly and took an early lead when James Tarkowski headed home from a set piece in the third minute. That, though, was as good as it got for the men in claret and blue. They will, however, be compact and hard to break down as always on Saturday.
Klopp may not be without skipper Jordan Henderson, who is back in contention after coming close to full fitness. The captain re-joined the squad later than usual following his exploits with England at Euro 2020.
Thiago Alcantara is also in the reckoning, with Klopp saying the pair, "look fine" and that he now need to "make the decision".
Defensive midfielder, Fabinho's father passed away on Friday and so the Brazilian is not expected to be in the squad to face Burnley. You'll Never Walk Alone, Fab.
Sean Dyche has now injury concerns following last week's defeat to Brighton, so could name an unchanged side as he looks to go three games unbeaten at Anfield.
With little to no transfer speculation of players leaving the club, the only rumour of note is the potential arrival of Lyon winger, Maxwel Cornet. The French club want to raise funds to launch a bid for Liverpool man Xherdan Shaqiri.
Predicted line ups
Alisson; Alexander-Arnold, Matip, van Dijk, Tsimikas; Oxlade-Chamberlain, Milner, Keïta; Salah, Jota, Mané.
Pope; Lowton, Tarkowski, Mee, Taylor; Gudmundsson, Westwood, Brownhill, McNeil; Wood, Barnes.
Last five meetings
Liverpool have won three of the last five meetings between the sides. The remaining two matches, however, have seen Burnley go two seasons unbeaten at Anfield.
Ashley Barnes' penalty gave his side a 1-0 in this fixture last season after Jay Rodriguez's strike earned the Clarets a point in 2019/20.
In the three games that Liverpool have won, though, they have hit 10 goals; two 3-0 away wins - one of those last season - and a 4-2 home victory showcasing just how lethal they can be.
Who to watch
It may be an obvious choice, but the Egyptian is worth his wait in gold and registered an assist for Roberto Firmino before finding the net himself last weekend. He always starts a season well and 2021/22 doesn't like it's going to be any different.
This isn't such an obvious choice. Chris Wood will undoubtedly be the man to stop as far as Liverpool's defence are concerned, but I reckon Josh Brownhill may dislodge Jack Cork from Burnley's starting XI. He's more progressive on the ball and loves to get stuck in which is exactly what Dyche's team will need on Saturday. He's got a shot on him, too.
How to watch
The Reds' first home game of the 2021/22 Premier League season kicks off at 12.30pm BST and will be broadcast live on BT Sport in the UK.