The Seagulls maintain a top-four position in the table while the Citizens are unbeaten since an opening-day defeat to Tottenham and are third, just two points off of top spot.
Ferran Torres is out for City as he continues to recover from a foot fracture.
John Stones' status is up in the air as the defender missed the Citizens' mid-week cup tie against Club Brugge due to personal reasons.
Brighton & Hove Albion: Sánchez; Burn, Dunk, Duffy; Cucurella, Lallana, Bissouma, Groß, Veltman; Trossard, Maupay
Manchester City: Ederson; Zinchenko, Laporte, Dias, Cancelo; Sliva, Rodri, de Bruyne; Grealish, Foden, Jesus
Ones to watch
Lewis Dunk (Brighton & Hove Albion)
Jack Grealish (Manchester City)
The 26-year old left Aston Villa to join the Citizens in a £100 million move and he has responded brilliantly, scoring two goals and assisting on two others and looks to be the force the champions thought he would be.
In May, Brighton overturned a two-goal deficit to record a 3-2 victory at the AMEX to stop an eight-match losing streak against City in all competitions.
Ilkay Gundogan scored in the second minute to give the visitors the early advantage and despite a red card being shown to Joao Cancelo in the 10th minute, Phil Foden struck three minutes into the second half to double the lead.
The match will be televised live on Sky Sports Premier League. Kick-off is set for 17:30pm BST.