The Potters have improved their form recently, with no defeats in their last four games in all competitions.
The Potters sit in 13th position and are six points from the coveted play-off places.
Birmingham City have endured a tough campaign at the wrong end of the table, and have won just two of their previous 13 games in all competitions.
The Blues sit 18th in the table with 36 points heading into this game.
Michael O'Neill has confirmed that playmaker Nick Powell faces a late fitness test on Saturday morning to prove his fitness for the Blues' visit, after picking up a hamstring strain against Nottingham Forest.
Romaine Sawyers has also trained this week, but is unlikely to be involved as soon as Saturday after a lengthy layoff.
Mario Vrancic and Abdallah Sima both return to action next week after respective knee and hamstring injuries.
Harry Souttar remains sidelined until the end of the season.
Blues fans were understandably delighted at the news of Tahith Chong making his return from a long-term groin injury this week, but Lee Bowyer has confirmed that he will not play a part in Staffordshire this weekend.
Club captain Troy Deeney has picked up a calf strain in training and is now likely to be sidelined for another month.
Stoke City (4-3-3)
Bursik; Wilmot, Harwood-Bellis, Jagielka, Tymon; Baker, Allen, Powell; Brown, Maja, Philogene-Bidace.
Birmingham City (3-5-2)
Etheridge; Colin, Mengi, Pedersen; Graham, Gardner, Woods, Bacuna, Bela; Taylor, Hernandez.
Ones to watch
Highly rated Philogene-Bidace is on loan to the Potters from Blues' crosstown rivals Aston Villa, and definitely looks to be enjoying his first taste of first-team football so far.
The 20-year-old winger netted his first goal for the club in a 3-0 win against Swansea City last week, and his performance saw him make the Championship Team of the Week. Stoke fans have a lot to be excited about with him in their attack for the rest of the season.
Another January loan acquisition, Taylor has struggled to replicate the form that saw him hit 11 goals in 22 Championship games for Charlton Athletic in the 2019/20 season since joining Nottingham Forest in 2020. January saw him link up with Lee Bowyer, under whom he enjoyed that great campaign for the Addicks.
This season's reverse fixture saw a bore 0-0 draw played out at St Andrews.
Stoke have won just one of their last eight league games against Birmingham - a 2-0 win in July 2020.
The Blues have kept a clean sheet in 11 of their last 15 league games against the Potters.
How to watch
The game kicks off at 15:00 GMT on Saturday February 19.
It is not available to watch in the UK but oversees supporters can purchase a live stream of the game via either club website.