Chelsea, who currently sit in sixth place after a mixed start to the season, will be looking to get their second win in a row against Southampton.
The Saints, who will be playing in front of a home crowd at St Mary's stadium, will be aiming to get back to winning ways after their loss to a rejuvenated Manchester United at the weekend.
Having lost to Leicester City at the weekend, the home side will be desperate to change their fortunes and move higher than their current 14th place in the Premier League table.
Thomas Tuchel will be back in the dug-out for the visitors after serving his one-match ban following his red card picked up during an alercation with Antonio Conte in their previous match against Tottenham Hotspur.
However, they will be without Conor Gallagher, who shone on loan for Crystal Palace last season and creating many goals for his team.
The Chelsea midfielder will be serving his ban following an unnecessary red card against the Foxes.
When asked about the strength of his squad, Tuchel stated "Right now, I think we could need some more players in some positions, but it's very close to the end of the transfer window.
"When September 1 comes, I will be a happy coach no matter what happens. I will try to find solutions and not think about what might have happened or what could be."
Southampton showed promise throughout their early kick-off match against Man United on Saturday and will be keen to recreate the positives on Tuesday evening.
New signings, Joe Aribo, Romeo Lavia and Armel Bella-Kotchap have brought a new dynamic to the Saints side as they fight to pick up points this season.
Team News
Southampton
The home side has no new injuries meaning manager Ralph Hassenhuttl will have plenty of options when he picks his starting XI.
Chelsea
While Gallagher will miss out through suspension, the suspended Kalidou Koulibaly will likely make his return following a ban for a red card he had previously sustained.
Mateo Kovacic returned from a knee injury at the weekend and will be available for selection while Tuchel has a dilemma on his hands on whether to start the new-signing Marc Cucurella or out of favour Ben Chilwell.
Likely Lineups
Southampton
Bazunu, Walker-Peters, Bella-Kotchap, Salisu, Perraud, Ward-Prowse, Lavia, A. Armstrong, Aribo, Elyououssi, Adams
Chelsea
Mendy, Chalobah, Silva, Koulibaly, James, Jorginho, Loftus-Cheek, Chilwell, Mount, Sterling; Havertz
Key Players
Chelsea - Raheem Sterling
After a slow start to his Chelsea career since his arrival from Manchester City, Sterling has started to find his groove and now has two Premier League goals to his name.
The English forward can play a pivotal role in creating chances and threatening the Southampton side's goal with his explosive runs both on and off the ball.
He now seems a guaranteed starter in Tuchel's Chelsea side and will likely cause the Saint's defense a lot of trouble.
Southampton - James Ward-Prowse
Ward-Prowse means everything to the home side. A master at creating opportunity and controlling the game whilst being defensively solid.
The Blue's will likely create more chances meaning if Ward-Prowse can get his side in the game at the other end then they could get a goal against the run of play.
Chelsea will also be cautious about conceding any fouls as the midfielder is one of the best when it comes to scoring goals from free-kicks.
Match details
Where is the game being played?
This one is being played at the Saint's home ground, St Mary's Stadium on the South Coast.
What time is the kickoff?
It gets underway on Tuesday the 30th of August at 19:45 BST
How can I watch it?
Along with all Premier League games on Tuesday evening, and indeed for the whole of this midweek, BT Sport will be covering this clash.
