Goals from Romain Perraud and Declan Rice ensured that the points were shared at St. Mary's.
A period of Southampton dominance got the action started. Their opening goal, after 20 minutes, was a fair reflection of the initial stages of the match. Perraud's deflected effort creeped past Lukasz Fabianski into the corner of the goal.
From that point on, West Ham put in a much improved performance. It took until the second half for the visitors to have their first attempt on goal - showing the wastefulness of their many first-half efforts.
An equaliser had certainly been coming. Declan Rice's brilliant effort, halfway through the second half, was the very least that West Ham deserved.
The result keeps Southampton in the relegation zone - they will require a huge improvement from today's performance, if they are to avoid remaining there for the rest of the season.
For West Ham, a respectable point, as they continue their recovery from a poor start to the season. For the time being, they move into 11th place in the table.
Story of the match
David Moyes was forced to deal with the absences of both of West Ham's current first-choice centre-back partnership. Kurt Zouma - due to illness and Craig Dawson - due to a leg injury picked up on Thursday, both dropped out of their most recent Premier League 11.
The pair, along with Pablo Fornals, were replaced by Vladimir Coufal, Ben Johnson and Emerson - meaning the visitors moved to a back five for today's fixture.
A familiar, trademark Ralph Hasenhuttl 4-4-2 was, again, the structure for Southampton. Ainsley Maitland-Niles and Mohamed Elyounoussi came into the team in the places of Ibrahima Diallo and Stuart Armstrong.
A quick start from West Ham led to an early corner, from which a good bit of pressing led to Gianluca Scamacca setting up Emerson - his first-time effort fizzed narrowly wide of Gavin Bazunu's goal.
That was the only worrying moment for a Southampton side, which settled into the game very nicely. In the first quarter of an hour, they moved the ball around with great intensity and quality - pinning West Ham back well into their own half, for most of the time.
The first major chance of the game fell to Che Adams. The powerful forward outpaced and later outmuscled Thilo Kehrer and found himself one-on-one with Lukasz Fabianski. He attempted to place a low finish past the keeper, but could only force him into making a routine save.
An ambitious, powerful effort from Scamacca, from around 35 yards, had Bazunu scrambling and ended up going very narrowly wide of the far post. The keeper was well beaten by this audacious attempt.
After 20 minutes, a lively passage in the game was rounded off, by the hosts getting the opening goal of the game. Kyle Walker-Peters' long throw was initially dealt with, but it eventually resulted in an effort from Perraud, from just outside of the area. A cruel deflection took the ball past the reach of Fabianski and it rolled into the corner of the goal.
Following the opener, the possession figures flipped - from Southampton's total dominance to West Ham's, for the rest of the first half.
The lively Adams had another great opportunity after 30 minutes. His low, left foot shot was very well saved at the near post by Fabianski.
Both teams' forwards were putting in very impressive displays. Scamacca produced a perfect cross into the path of the marauding Lucas Paqueta - his header wrong-footed the keeper and clipped the post on it's way wide just wide of the goal.
A powerful effort from Elyounoussi was Southampton's sixth effort on goal of the half, compared to West Ham's none. It was the visitors who actually had the superiority in total attempts, heading into the break, but none of their 10 efforts tested Bazunu.
After the restart, West Ham looked to continue the slight bit of momentum they gathered, following Southampton's goal. Jarrod Bowen's cross was almost redirected on target by Scamacca, but from an uncomfortable height, he could only send the ball over the bar off of his knee.
A few minutes later, a powerful strike from Paqueta was the visitors' first effort on goal - Bazunu made a good save. The Saints responded with a dangerous counter-attack, which forced Aaron Cresswell into making an important challenge to avert away serious danger.
On the hour mark, the introduction of Said Benrahma, in place of Emerson, signified Moyes changing to the 4-2-3-1, in an attempt to find a much-needed goal.
The substitute played a crucial part in West Ham's equaliser, just a few minutes later. A lovely bit of link-up between Cresswell, Benrahma and Rice, down the left hand side, led to the England international producing a perfect, whipped effort into the far corner.
Southampton seemed to be reeling. An awful pass from Mohammed Salisu gave the visitors a chance to counter. Attempts by Paqueta and Benrahma were both blocked, as Salisu majorly got away with one.
West Ham continue their wave of pressure. A penalty shout was turned down by the referee and VAR, as the ball struck Salisu's arm, following a touch from Bowen. Another Rice effort from range was well blocked and redirected for a corner.
A quadruple change from Hasenhuttl after 74 minutes was a sign of the need for serious changes for Southampton. Entering the final quarter of an hour, it seemed there was only going to be one team who may get a late winner.
The drastic changes did enough to calm the brewing West Ham storm. In the next few minutes, for the majority of the visitors' possession, the volume of chances and danger to Southampton's goal had decreased.
It took until the 83rd minute, for West Ham to fashion another good opportunity. Paqueta's through ball allowed Scamacca to have a left-footed effort on goal, which was kept out by Bazunu.
The visitors were unable to get a late winner, which they continued to push for, until the final whistle. West Ham had 15 efforts at goal in the second half, compared to Southampton's two. It was a very drab performance from the hosts and one that West Ham can feel fairly positive about.
Player of the match - Declan Rice
A fantastic goal was the highlight of another impressive performance from West Ham's star man.
He was an important presence, both in and out of possession - misplacing just three out of his 69 attempted passes.
