A 1-1 draw away to West Bromwich Albion was followed by a dominant 4-0 win over Real Sociedad in the Europa League and Ole Gunnar Solskjaer's side now turn their attentions back to the Premier League.
Here is how the two sides shape up ahead of Sunday's game.
Paul Pogba continues to be sidelined following his withdrawal against Everton earlier this month as he joined Phil Jones on the injury list. The Frenchman had displayed scintillating form prior to his injury and his absence has been felt as of late.
There are doubts surrounding Scott McTominay for this fixture after the midfielder was forced off through injury on Thursday while there also question marks over the fitness of Donny van de Beek and more worryingly, Edinson Cavani as the pair did not travel to Turin midweek.
On a more positive note, Eric Bailly returned to action against Sociedad having not featured since the win over Fulham on the 20th January. The Ivorian will provide a much needed boost to the defence and could slot in next to Harry Maguire.
The Magpies will be without their top goal scorer Callum Wilson for this game as the striker picked up an injury in their 3-2 win over Southampton. With 10 goals and five assists to his name this season, he will be sorely missed by his teammates.
Defenders Fabian Schar and Javier Manquillo are set to miss this fixture as they join Federico Fernandez on the list of absentees having also suffered injuries against the Saints two weeks ago.
However, Jeff Hendrick will be available for selection as he returns from suspension having missed his side's last match against Chelsea.
Man United: De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, Fred, Matic, Greenwood, Fernandes, Rashford, Martial.
Newcastle: Darlow, Krafth, Lascelles, Clark, Lewis, Willock, Hayden, Shelvey, Almiron, Gayle, Saint-Maximin.