The Seagulls haven't tasted victory in the Premier League since September 19th, but remain in the top half of the table.
Just three points above the relegation zone, the Whites are coming off of a 2-1 defeat to Tottenham Hotspur on Sunday.
Brighton & Hove Albion: Sanchez; Cucurella, Duffy, Dunk, Veltman; Lallana, Bissouma; March, Trossard, Lamptey; Maupay
Leeds United: Meslier; Cooper, Phillips, Llorente; Harrison, Klich, Struijk, Dallas, Raphinha; Rodrigo; James
Ones to watch
Yves Bissouma (Brighton & Hove Albion)
Made a few vital challenges against Aston Villa when they looked to break and tracked back well. With an unflappable demeanor being one of his many attributes, it's not hard to see why clubs such as Arsenal and Liverpool are interested in the midfielder.
Raphinha (Leeds United)
The Whites leading scorer with five goals, the Brazilian has starred in all areas of the game. His pace, ability to get past defenders and left foot make him a handful for any Premier League defense.
Brighton did the double over Leeds last season, winning 1-0 at Elland Road before bagging a 2-0 victory at home.
The match will be televised by Sky Sports Premier League. Coverage begins at 5pm with kick-off set for 5:30pm.