The Hammers were one of the seeded teams in the draw, meaning they will play the away leg first, currently scheduled for Thursday 10th March at 5:45 PM GMT, which is an hour ahead on the continent.
David Moyes' side will then face Los Rojiblancos at the London Stadium a week later, with kick off at 8:00 PM GMT in the decisive second leg, which will be one of the biggest games in recent memory for the club.
Of course, it's important to remember that in all European competitions this season there is no longer the 'away goals rule,' meaning any goals West Ham might score in Spain won't count for any more in the event of an aggregate draw.
Instead, both sides will face the prospect of heading for extra time in the English capital, and if that still can't separate them, they'll go to a penalty shootout, competing for a place in the quarter finals of the competition.
Here's how various people reacted to the draw for West Ham as it was made on Friday lunchtime...
'Pick of the round'
'From what I've seen, I think our Europa League round of 16 tie with Sevilla is the pick of the round,' the 58-year-old told the media just a couple of hours after the event.
The Scot clearly has the utmost respect for his upcoming continental opponents too, going on to praise the Spanish outfit both for their long-term stature as a European giant as well as their current form this season.
'I think Sevilla has an unbelievable historian winning the competition and I know their manager Julen [Lopetegui] [...] after Real Madrid they're probably the most in-form team in Spain at the moment so it'll be a really tough game [...].'
He's not wrong to point to Sevilla's record with this competition - they've won it a record six times - and they're also currently five points clear in second place in La Liga, ahead of fellow rivals in the Europa League Real Betis and Barcelona.
There was a slight twinge of disappointment from the coach that he wouldn't go up against a team from his hometown of Glasgow in Rangers ('I was looking forward to maybe having a game against them') but it's clear he's more than happy with the draw West Ham have.
West Ham United (@WestHam) February 26, 2022
Plus, while it was clearly said in jest, he already appears to have his eyes set on the final, commenting: 'It would be good to go there [Sevilla's stadium] twice for the final, so it would be good to get used to the stadium wouldn't it!'
'A tough tie'
Meanwhile, one of the Hammers' most talented players in Declan Rice gave his thoughts and while he was looking forward to the prospect of going up against such a big team, there was a sense of caution too.
'They're a massive club, it's going to be a tough tie,' the Englishman said, while also remarking 'but if we want to compete with the best and test ourselves against the best then we've got to beat the best.'
'We're all excited, all the lads and the manager and of course the fans are looking forward to it.'
Speaking of fans looking forward to the game, that message was echoed by former West Ham striker Tony Cottee, who scored 115 league goals for the Hammers' over the course of two separate spells at the club.
He reacted to the draw on Twitter in a way many other fans of the club probably did too, while also following the same line as David Moyes in his optimism over potentially reaching the final come May.
Well, I always said that we would get to Seville, just thought it would be in May not March!!!!— Tony Cottee (@TonyCottee9) February 25, 2022
Tough draw, looking forward to going to Spain with 1,000s of fellow hammers come on you irons #UEL #WHUFC #COYI #westham pic.twitter.com/PhrKS1vV0g
There were also reaction from European football journalist Julien Laurens, who spoke to TalkSport moments after the draw had been completed, talking of how Sevilla would not see this as an easy tie by any means.
'I think this is one that if West Ham put their strongest team out and have good momentum going into the game they will cause problems for this Sevilla team,' he told the radio station.
Thoughts from the fans
Finally, here's a selection of the very best tweets from West Ham United supporters reacting to the draw in real time and after the event, with it being fair to say that there has been a slightly mixed reaction in terms of optimism heading towards the match.
Some are feeling positive...
Standard of performance has understandably dropped in recent weeks but shows how far this current team under Moyes has taken the club when West Ham have just drawn Sevilla in the round of 16 in a meaningful European competition. Couldn’t imagine this happening a few seasons ago.— Josh V (@WestHamJoshV) February 25, 2022
...others not so much.
A fan confused over the pessimism...
Don’t understand the negativity, great tie ⚒— Lewis ⚒ #GSBOUT (@darylwhu) February 25, 2022
What we wanted European nights for, no?
...and another just looking forward to the challenge.
Why all the negativity with the draw we are in a european competition last 16 something the majority of fans can only have dreamed about.Yes its Sevilla but lets wait for the games to be played,were not favourites but people seemed to have given up already— David foss (@Davidfoss63) February 25, 2022
There's a dose of realism here...
A tough Europa League round of 16 draw for us Hammers. Sevilla are a record 6 times winners of the competition (2006, 07, 14, 15, 16 & 20) and currently 2nd in La Liga.— Bobby Seagull (@Bobby_Seagull) February 25, 2022
Hopefully this will inspire our players to rediscover some of our early season form. #UEL #COYI
...and seemingly the most popular reaction here.
The draw in full
Ties to be played w/c 7th March and w/c 14th March