New Brighton and Hove Albion manager Fabian Hürzeler has been backed heavily by Tony Bloom this summer, with the Seagulls spending over £100m on five players as things stand - and with rumours of more additions pending.
As for Everton, they have continued to struggle in the transfer window due to profit and sustainability restrictions.
However, the Toffees have profited overall in the window after the sales of Amadou Onana, Ben Godfrey and Lewis Dobbin for a combined £75m - while only bringing in £45m worth of talent.
Brighton have an impressive recent record at Goodison Park, going unbeaten there in their last three visits to Merseyside, but they face a manager in Sean Dyche who has only lost four times across 20 matches against the Seagulls in his managerial career.
The last time these two met was at the American Express Community Stadium last February, when a 10-man Brighton that afternoon equalised in the fifth minute of stoppage time through their captain Lewis Dunk.
Dunk's goal was set up by Albion legend Pascal Gross, who left the south coast earlier this summer to join his boyhood club Borussia Dortmund in a major loss for Hürzeler's side.
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Team news
Everton
Despite holding onto their star man at the back in young centre-back Jarrad Branthwaite amid interest from Manchester United, Everton will be without the 22-year-old this weekend due to a groin injury.
Club captain Seamus Coleman and Nathan Patterson are also out, leaving the Toffees weaker than they would like at the back, while in midfield, James Garner has a calf injury that will keep him out until the end of the month.
Striker Dominic Calvert-Lewin is available, however he has not ruled himself out of a move away from the Toffees this summer.
Thankfully, they have former Seagull Neal Maupay back at the club following a successful loan spell at Brentford, where he averaged a better minutes-per-goal (MPG) rate in the Premier League last season (237 MPG), than Calvert-Lewin (312 MPG).
Brighton
The visitors were plagued by injuries last season and still have a number of players including Solly March, Pervis Estupiñán and Evan Ferguson out with long-term knocks.
Meanwhile, both Bart Verbruggen and Julio Enciso picked up short-term injuries while representing their countries at the Euros and Olympics respectively.
It is unlikely for Igor Julio and Tariq Lamptey to start, but they could return to the bench.
However, Billy Gilmour is unlikely to feature at all with a reported move to Antonio Conte's Napoli on the horizon.
Last season's top goalscorer João Pedro missed the majority of pre-season through injury, but he returned with a goal last weekend in the Seagulls' impressive 4-0 win over Villarreal.
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Likely lineups
Everton:
Pickford; Young, Tarkowski, O'Brien, Mykolenko; Harrison, Gana Gueye, Doucouré, McNeil; Calvert-Lewin, Ndiaye.
Brighton:
Steele; Veltman, Dunk, Van Hecke, Barco; Wieffer, Baleba; Minteh, Pedro, Mitoma; Welbeck.
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Key Players
Everton - Jake O'Brien
Young centre-back O'Brien is certainly one to watch for the Toffees this season following his arrival from Lyon.
Not only is the Irishman a solid defender, but he is an aerial threat which Dyche's side will need in the absence of Branthwaite.
Last season for Lyon, O'Brien scored five goals from centre back and he has already shown in pre-season that his presence can cause havoc in the opposition box, netting in Everton's 3-0 win against Preston North End earlier this month.
On his Premier League debut, the 23-year-old will have his work cut out for him against the experienced Danny Welbeck, but it should be a challenge which he relishes.
Brighton - Yankuba Minteh
Brighton's record summer signing Minteh has already proved to Seagulls supporters exactly why Tony Bloom splashed the cash on his signature early on in the transfer window.
The winger has impressed with his incredible first touch, sharp turn of pace and most importantly his eye for goal.
The Gambian scored in both of Brighton's pre-season friendlies in Japan before scoring and assisting last time out against Villarreal.
Often teams would double-up on Karou Mitoma down Albion's left flank, but with Minteh causing chaos down on the right-hand side too, opposing defences will struggle to contain both at once.
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Match Details
Where is the game being played?
Goodison Park is the stage for this meeting, and this will therefore be the final time ever that the Seagulls will visit Goodison in league action, with Everton scheduled to move into a brand-new stadium next season.
What time is kick-off?
It is a traditional Saturday 3pm kick-off this weekend for these two. It is the same scenario for three other matches this weekend too.
How can I watch?
The only place to watch this one live is in the flesh at Goodison Park. Highlights will be shown on Match of the Day on BBC One at 22:30 BST on Saturday night.
