A perfect three wins from three have put West Ham in a comfortable lead at the top of Group B of the UEFA Europa Conference League.
With all of Anderlecht, Silkeborg and FCSB picking up points against each other, The Hammers are five points clear of tomorrow's opponents, at the halfway point of the group.
A win tomorrow would ensure at least second place - a spot in the play-off round, against one of the third-placed teams from the UEFA Europa League group stage.
However, West Ham will have their sights firmly set at consolidating top spot in the group. A win tomorrow and FCSB picking up at least a point at home against Silkeborg will seal the group win for tomorrow's hosts.
This will be a rematch from last week's meeting between the two teams, in Belgium. Gianluca Scamacca came off the bench to seal a 1-0 win, after West Ham dominated for much of the evening.
The Hammers continued their good form, with a 3-1 comeback win against Fulham, on Sunday. Anderlecht also enjoyed a productive domestic weekend, by completing a 3-1 comeback of their own, against KV Mechelen.
Team News
West Ham
David Moyes will be forced to make a late decision on Michail Antonio's availability for tomorrow's game. The forward had missed training, following the Fulham game, as he was battling illness.
As a result, Scamacca may be called to start back-to-back West Ham games - giving the Italian forward a chance to extend his three game scoring streak, prior to the weekend's fixture at Southampton.
A further update on Nayef Aguerd from Moyes was: "he is beginning to make his way and is doing quite a bit out on the grass. I’m hoping next week he might join bits of the football, that’s the plan if we can" - a positive sign for West Ham and, particularly, Morocco supporters, ahead of the upcoming World Cup.
Maxwel Cornet - who suffered a calf injury a few weekends back, in the game against Wolves, is expected to return into full training sometime next week.
Yet again, fairly significant changes to the West Ham 11 are expected. Ben Johnson, Vladimir Coufal, Angelo Ogbonna, Emerson, Flynn Downes, Manuel Lanzini, Said Benrahma and Antonio are all in strong contention to return to the starting 11 and resemble much of the team which took to the field in last week's game, against the same opposition.
Anderlecht
Like his counterpart, Felice Mazzu may also look to name a team, resembling that from last week's fixture.
The 18-year-old Mario Stroeykens was the star of the weekend for Anderlecht. With his team 1-0 down against Mechelen, he was introudced at half-time and scored two goals and aid his team complete a much-needed comeback win.
Fellow 18-year-old - Julien Duranville, impressed hugely in his substitute appearance against West Ham, last week. He played in a wing-back role, but is also capable of occupying the forward areas.
The pair of youngsters will be in with a chance of earning a starting spot tomorrow.
There are no new injury concerns in the Anderlecht team, compared to last week's reverse fixture.
Predicted Lineups
West Ham
(3-4-3) Areola; Johnson, Dawson, Ogbonna; Coufal, Lanzini, Downes, Emerson; Paqueta, Benrahma, Scamacca.
(3-5-2) van Crombrugge; Debast, Hoedt, Delcroix; Murillo, Diawara, Ashimeru, Amuzu, Verschaeren; Refaelov, Silva.
Key Players
West Ham - Flynn Downes
The summer signing has only made two West Ham starts, following his move from Swansea. However, on both starts, coming in the UECL, he put in hugely impressive performances.
There have been calls among the fanbase for Downes to earn the chance to start in the recent Premier League games. Tomas Soucek's recent improved form has not allowed for that to happen, just yet.
Should Downes continue his run of brilliant European games, then it will certainly not take long for him to earn his first Premier League start.
Anderlecht - Zeno Debast
Anderlecht's plethora of young talents is represented by the fact that another 18-year-old is being mentioned in this preview.
Debast put in a very impressive performance against West Ham last week. He was able to keep up with Antonio in a few physical battles and looked a very composed presence in the team's backline.
The impressive Debast has been a crucial part of Anderlecht's squad, this season. He has started all but one of their domestic and European fixtures this seaosn.
Match Details
Where is the game being played?
The game will take place at London Stadium - the home of West Ham.
What time is kick-off?
This match is one of the late kick-offs of Thursday's European schedule. It is set to kick-off at 20:00 BST.
How can I watch?
The game is scheduled to be broadcasted in the U.K. on BT Sport 2.