England will be without four players for their international friendly with Italy in Turin this Tuesday.
Danny Welbeck, Raheem Sterling, James Milner and Leighton Baines have all been ruled out of the encounter with minor injuries, with Southampton's Ryan Bertrand called up as a replacement for Baines.
Arsenal forward Welbeck is the latest addition to the injury list, having sustained a knee injury after scoring in the Three Lions' regulation 4-0 win over Lithuania on Friday night in Euro 2016 qualifying.
Sterling, who netted his first international goal in that game, was already ruled out with a toe injury but England boss Roy Hodgson was hopeful Welbeck might have been fit to feature again.
"We knew we were going to be losing Raheem Sterling who had an injection last night on an on-going injury and hopefully that will help him as we go forward," Hodgson said.
"We have a problem with James Milner who had to leave, we decided to let Leighton Baines go home and of course we lost Danny Welbeck who unfortunately picked up a slight knee injury against Lithuania. So those four players won't be with us going forward but it means a chance for the other guys in the squad to show what they can do.
"We are going to bring Ryan Bertrand in because with Leighton Baines gone we are now left with only one recognised left-back which is Kieran Gibbs. We wanted two recognised left-backs for both games."
With Welbeck out of the picture, the friendly could see a first England start for in-form Spurs forward Harry Kane. The 21-year-old forward came off the bench to score barely a minute into his international debut against Lithuania at Wembley.
The game will be the first time the two sides have met since goals from Claudio Marchisio and Mario Balotelli helped the Azzurri to a 2-1 win in their first match of the 2014 World Cup in Brazil.
Liverpool's Daniel Sturridge, who scored England's consolation in that encounter, is also unavailable due to a hip injury.