It's a must win match for both sides as the Bundesliga enters the penultimate games of the season.
Stuttgart are currently bottom of the table, one point from safety. Hamburg are one point clear of safety so a win for either team will put the other side under an enormous amount of pressure going into the final game of the season.
In team news, Huub Stevens will be hoping a key trio from their 2-0 win over Mainz last weekend - Daniel Didavi, Geoffroy Serey Die and Antonio Rüdiger - will be fit this weekend. All three were training separately during the week due to knocks and it remains to be seen whether they will be fit for Saturday.
For the visitors, Valon Behrami will miss the trip to Stuttgart, with Gojko Kacar deputising for him once again. There was good news from the treatment room, though, with both Ivo Ilicevic and Cleber returning to team training this week, and both are therefore on the frame to start.
Speaking ahead of the big game, Hamburg coach Bruno Labbadia said: "I really hate relegation battles,but even when it's not easy in our situation, you've also got to be able to enjoy yourself.''
Stuttgart's home form has been impressive recently, unbeaten in five and winning three of those. A stat that will have to continue if they are to get themselves out of trouble.
Hamburg's away form is not as impressive. They have lost five out of their last six games on their travels, although a 2-1 win at Mainz 05 in their last awayy match will give them some hope going into the game.
Possible line-ups:
Stuttgart: Ulreich - Schwaab, Baumgartl, Rüdiger, Klein - Serey Dié, Gentner - Harnik, Didavi, Kostic - Ginczek
Hamburg: Adler - Westermann, Djourou, Rajkovic, Ostrzolek - Van der Vaart, Kacar – Stieber, Jansen, Olic - Lasogga