Borussia Dortmund travel to the Volkswagen Arena looking to get themselves secured to a Europa League Spot.
Vfl Wolfsburg, however, will be hoping to cement second place with a win over Jurgen Klopp's men.
The two sides will meet again in Berlin later in the month for the DFB-Pokal final so this game will be a taster for the 30th May.
Wolfsburg are guaranteed UEFA Champions League football next season and are now battling with Borussia Mönchengladbach for second place. Dortmund retain hopes of playing in Europe next season as well, which they can secure by finishing in the top six or by beating Wolfsburg in Berlin.
In team news, The Wolves have one eye already on that meeting with Dortmund in Berlin, no risks will be taken with any players showing signs of fatigue. Marcel Schäfer, Luiz Gustavo and Ivan Perisic are carrying knocks but may still feature, while Xizhe Zhang could make his Bundesliga debut.
For Dortmund, main man Marco Reus is fit again and set to get some minutes under his belt ahead of the final. Meanwhile, Sven Bender and Sebastian Kehl are the only two doubts for Jürgen Klopp.
Just one loss in five Bundesliga games has allowed Dortmund to climb up the table once again, and they have piled the pressure on Augsburg and Schalke 04 with two league matches remaining.
Talking about Reus' return, Klopp said: "We've not been preserving him, he's just not been given the green light by the medical department yet, which is why he has not been able to play,''
"It wouldn't make any sense to take a player out for three weeks without reason anyway. But he was able to warm up yesterday and we hope he can train normally and be an option.''
Wolfsburg boss Dieter Hecking is expecting a really tough test when Dortmund arrive: "I'm sure they will play with their strongest team here, so it promises to be an exciting game to watch.''
The good news for Wolfsburg is that Bas Dost has found his form once again after a difficult spell in front of goal, and three goals in the past two weeks will mean that the Dutchman is full of confidence heading into the game.
The hosts have won just one of the last five matches between the two sides in all competitions.
Possible line-ups:
Wolfsburg: Benaglio - Träsch, Naldo, Klose, Rodriguez - Guilavogui, Luiz Gustavo - Perisic, De Bruyne, Caligiuri - Dost
Borussia Dortmund: Langerak - Durm, Subotic, Hummels, Schmelzer - Kehl, Gündogan - Mkhitaryan, Kagawa, Kampl - Aubameyang