Italy and France will each be without one of their star players when they take the field for their Rugby World Cup opener at Twickenham.
Italian captain and talisman Sergio Parisse has not recovered from his surgery in time to play, yet his country are hopeful he can return later in the tournament.
For France, star centre Wesley Fofana misses out with a thigh injury, with his place in the team taken by Alexandre Dumoulin.
History against Italy in World Cup opener
Having won just two of the 16 clashes between the two nations in this century, Italy go into the game against France with history far from on their side.
Add that to the loss of Parisse, and it's clear that the Italians will be up against it at Twickenham.
Parisse's spot in the team goes to Saracens' Samuela Vunisa who impressed during the 2015 Six Nations, with hooker Leonardo Ghiraldini taking over as hooker.
Talking about the loss of Parisse, head coach Jacques Brunel said, “We have to respond as a squad and the other players have to fulfil their roles, not just the experienced players, but everyone.
“Vunisa was the strongest replacement and has played this role before. The main responsibility for the number eight comes in the scrum and France’s scrum is one of the strongest around.”
French retain side from England win
France were extremely impressive in their final warm-up game for this World Cup, beating England in Paris, and have retained 14 of the starters, with only the injured Fofana missing out.
Sebastien Tillous-Borde and Frederic Michalak start in the half-backs, with Yoann Huget on the left wing.
Commenting on the loss of Fofana, head coach Philippe Saint-Andre said, "He is not out of the 23 on ability. I expect he will be 120 per cent on Wednesday (when the French face Romania)."
How the sides line up
Italy:
1. Matias Aguero, 2. Leonardo Ghiraldini (captain), 3. Martin Castrogiovanni
4. Quintin Geldenhuys, 5. Josh Furno
6. Alessandro Zanni, 7. Francesco Minto, 8. Samuela Vunisa
9. Edoardo Gori, 10. Tommaso Allan
11. Giovanbattista Venditti, 12. Andrea Masi, 13. Michele Campagnaro, 14. Leonardo Sarto, 15. Luke McLean
Replacements: 16. Andrea Manici, 17. Michele Rizzo, 18. Lorenzo Cittadini, 19. Valerio Bernabo, 20. Simone Favaro, 21.Guglielmo Palazzani, 22. Carlo Canna, 23. Enrico Bacchin
France:
1. Eddy Ben Arous, 2. Guilhem Guirado, 3. Rabah Slimani
4. Pascal Pape, 5. Yoann Maestri
6. Thierry Dusautoir, (c) 7. Damien Chouly, 8. Louis Picamoles
9. Sebastien Tillous-Borde, 10. Frederic Michalak
11. Noa Nakaitaci, 12. Alexandre Dumoulin, 13. Mathieu Bastareaud, 14. Yoann Huget, 15. Scott Spedding
Replacements: 16. Benjamin Kayser, 17. Vincent Debaty, 18. Nicolas Mas, 19. Bernard Le Roux, 20. Alexandre Flanquart, 21. Morgan Parra, 22. Remi Tales, 23. Gael Fickou