Tottenham Hotspur and Manchester United have been competing with each other on a more even playing ground since the retirement of Sir Alex Ferguson in 2013.
Since the 2013/14 season, until the present; Spurs have finished above United four times, and United have triumphed in terms of league positions only three times.
The Red Devils look set to finish ahead of the North-London club this season, as they comfortably sit in second behind runaway leaders Manchester City.
This sets the scene for a thrilling tie between the two as the teams meet at the Tottenham Hotspur Stadium on the 11th of April.
When facing each other head to head, the 13-time Premier League winners come out on top. Out of the total 194 meetings between the two, United have won 92, drawn 49, and lost 53.
Narrowing this down a little, their last 10 match-ups have resulted in five United wins, one draw, and 4 losses to Spurs.
Spurs will be looking to build on their victory earlier in the season at Old Trafford, and claw back some of the ground in the race for the top four as we approach the culmination of the 20/21 season.
Here we can recall some of Spurs' most memorable wins against Manchester United, as they seek to do the double against them for the first time ever in the Premier League.
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Manchester United 1-6 Tottenham Hotspur (October 2020)
Earlier in the campaign, a fiesty encounter played out between the two teams, which saw a red card, seven goals, and two penalties.
When an early penalty was converted by Bruno Fernandes, Spurs fans will have feared the worst. However, instant response and goals from Tanguy Ndombele and Heung- Min Son propelled Spurs into the lead.
A red card was issued in the first half for Frenchman Anthony Martial for a raised hand on Erik Lamela, and this paved the way for Spurs to score their third.
Dangerous play from the United defence allowed Spurs to win the ball high up before Harry Kane slotted home Spurs' third.
It was plain sailing for the Lilywhites in the second half as Son scored again. Serge Aurier added a fifth before a silly challenge from Paul Pogba gave Kane the chance to really embarrass United from the spot, which he did.
Spurs boss Jose Mourinho will undoubtedly use this game as a means to motivate his players in the return fixture at the weekend, as it is certainly one that will be remembered by fans for years to come.
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Manchester United 0-3 Tottenham Hotspur (August 2018)
At the peak of Mauricio Pochettino's power, Spurs were playing attacking, fluid and mesmerising football at times.
This was emulated in yet another encounter at Old Trafford when the sides met in the Premier League in 2018.
Harry Kane was involved yet again as he rose highest from a Spurs corner to give the visitors the lead in the 50th minute.
Spurs doubled their lead just two minutes later as Brazillian Lucas Moura finished superbly to set his side on course for victory.
As United pushed for a way back into the tie, Spurs hit them with a devastating counter-attack, as Man of the Match Moura secured an impressive three points for Pochettino's men.
This match will be remembered by Spurs fans as it was the first time in four years that Spurs had managed to score a goal at Old Trafford, let alone win the match.
As well as this, it helped constitute the club's best start since 2009 to a league campaign, winning all three opening matches.
The icing on the cake will have been the fact that Spurs had inflicted United boss' Jose Mourinho's biggest home defeat in his career.
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Tottenham Hotspur 2-0 Manchester United (May 2017)
This game is remembered by Spurs fans for more than just the opponent.
This encounter happened to be the last game ever played at the old White Hart Lane Stadium.
On the day, there was overwhelming desperation to win and complete an undefeated season at home in the stadium's final event.
Having beaten Arsenal just a few weeks before, the players approached the game with no fear and they were clearly brimming with confidence when the whistle blew to start the encounter.
A superb cross by Ben Davies was met by Victor Wanyama to give the hosts an early lead before Kane latched on to a Christian Eriksen free-kick, eventually slotting home and doubling Spurs' advantage.
A late Wayne Rooney penalty meant that he went down in history as the last player to score a goal in the stadium, but Spurs held on for the win, which was met with a monumental wave of noise from the supporters.
The win meant that Spurs had gone undefeated at home for the first time since the 1964-65 season. As well as this, they recorded their 14th consecutive home league wins equalling their record set in 1987 (BBC).
The game was followed by an emotional farewell ceremony, and a rainbow appeared over the roof of the ground, marking the end of an era for the North London club.
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Tottenham Hotspur 3-0 Manchester United (April 2016)
During that bizarre season in which Leicester City went on to win the Premier League, Spurs mounted a fierce title challenge of their own.
Although they eventually fell short, Spurs emphatically defeated United at home 3-0.
The memorable part of this game came through the three goals scored within six minutes on this sunny Sunday afternoon.
Dele Alli was emerging as a potential superstar and he opened the scoring in the 70th minute, slotting past David De Gea from close range.
Just four minutes later, Toby Alderweireld directed a looping header into the back of the net to double Spurs' advantage, before Erik Lamela put the lid on the victory, keeping Spurs in touch with Leicester.
This was the first time that Spurs had beaten United at home since 2001. Pochettino was winless in the previous six games against Louis Van Gaal's side.
Pochettino's side restricted the Red Devils to just one shot on target in the entire game, as they reduced the gap at the top to just seven points.
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Manchester United 2-3 Tottenham Hotspur (September 2012)
The major significance of this game was that it was the first time since 2001 that Spurs had taken all three points from United.
Even more significant is the realisation that this match ended Spurs' 23-year wait for a victory at Old Trafford.
An own-goal from Jonny Evans gave Spurs the lead in the second minute as Jan Vertonghen and Gareth Bale linked up superbly to maneuvre the breakthrough.
Bale was at it again in the 32nd minute as he weaved through the United defence before slotting past Anders Lindegaard.
The game really came to life when there was a flurry of three goals in 139 seconds as the hosts pulled one back through Nani before Clint Dempsey followed up a Bale shot to restore the visitor's two-goal advantage.
Shinji Kagawa played a neat one-two with Robin Van Persie to put the game on a knife-edge, but Spurs managed to hold on in what was a truly pulsating match.
The events of the game speak for themselves when it comes to listed memorable wins for Spurs, and this one more than warrants a place on the list.