That poor run means the Hornets find themselves 17th in the Premier League, just two points above the relegation zone, albeit with games in hand on some of the teams around them due to Covid-19 related postponements.
Conte's side currently sit 7th in the Premier League, but like Watford, have games in hand on some of their rivals.
If they were to win these matches, the six points gained would currently take them into the top four ahead of Arsenal.
Fellow full-back Danny Rose will also miss the visit of his former club due to a knee problem.
Watford have also confirmed some players are continuing to isolate under Covid-19 protocols, though the identities of these players has not been revealed.
The team news for Spurs is more brief, with midfielder Giovani Lo Celso recovering from injury to be available for the game.
Spurs Head Coach Antonio Conte however, confirmed at his press conference that Cristian Romero, Steven Bergwijn and Ryan Sessegnon are all still out injured and will therefore miss the trip to Watford.
Managers have their say
In their pre-match press conferences, both managers had their say on this weekends fixture.
Watford Head Coach Claudio Ranieri was full of praise for fellow Italian Antonio Conte ahead of the match.
"Antonio is a fantastic manager, where he goes, he changes the team. And Tottenham now is a very strong team, he wants to arrive in the Champions League, and I think at the end he will achieve that," said the Italian.
"His attitude, his strength, his quality. He convinces his players to do everything, he convinces also the board to buy good players. He is a fantastic manager. He is a fantastic man."
Meanwhile, Conte was fully focused on Spurs getting all three points at Vicarage Road.
“My expectation is that this is the first game of the new year but my expectation is always the same, to play a really good game then try to get the three points," said the Spurs Head Coach.
“My expectation is this. We know very well it won’t be easy.
“Watford will want to do the same but we have to think to ourselves to try to continue to improve game by game and to be better. To be better in many aspects that we’re working on," Conte continued.
"The most important thing for us is the three points."
Watford predicted XI: Bachmann; Masina, Cathcart, Sierralta, Kucka; Louza, Sissoko, Cleverley; Hernandez, King, Dennis.
Spurs predicted XI: Lloris; Tanganga, Dier, Sanchez; Reguillon, Hojbjerg, Skipp, Royal; Lucas Moura, Son Heung-Min; Kane
How to watch
Watford vs Tottenham Hotspur is a 3PM kick-off on Saturday, 1st January.
The game can not be watched live on television in the United Kingdom.