Following their respective away victories in the Carabao Cup midweek, the Saints will visit the Bees to try and secure their first three points upon their return to the Premier League.
Brentford travelled to League Two Colchester for their second round tie in the Carabao Cup, a fixture where they edged past with a 0-1 victory.
As for Southampton, they made the trip to Wales to face Championship side Cardiff, coming away with a 3-5 win in an absolute thriller. Matues Fernandes opened the scoring on his full debut and Cameron Archer netted a brace on his first start for the club.
Last time out in the league, Brentford fell to defeat against Arne Slot's Liverpool during his first home game for the Reds, whilst Southampton suffered a rather disappointing loss to Nottingham Forest after failing to perform anywhere near the levels they showed at Newcastle a week prior.
Ahead of the international break next weekend, both teams will want to end positively, especially Southampton who are yet to get a win under their belt.
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Team News
Brentford
Ivan Toney won't be playing for this Brentford side on Saturday, with the attacker yet to feature in a squad this season for Thomas Frank.
The English international is looking for a move elsewhere before the transfer window shuts - with a fee being agreed with Saudi Arabian club Al Ahli.
Igor Thiago, Aaron Hickey, Rico Henry and Joshua Dasilva are also unavailable, with Hickey possibly missing out on the remainder of the season.
Southampton
After Southampton's mid-week game in the Carabao Cup, they have a clean bill of health. Adam Lallana has returned to the side and he came on as a substitute in their 3-5 win.
Aaron Ramsdale has officially been unveiled as a new signing for the Saints, although it is unclear as to whether he was registered in time to play.
Ross Stewart and Kamaldeen Sulemana may not be fit enough to return to the Southampton squad just yet.
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Likely Lineups
Brentford
Flekken; Roerslev, Collins, Pinnock, Ajer; Jensen, Norgaard, Janelt; Mbeumo, Wissa, Lewis-Potter.
Southampton
Ramsdale; Walker-Peters, Bednarek, Harwood-Bellis, Sugawara; Fernandes, Smallbone, Downes; Brereton Diaz, Archer, Armstrong .
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Key Players
Brentford - Bryan Mbeumo
The Brentford attacker has already opened his account in the Premier League this season, and it only took him 29 minutes on the opening day against Crystal Palace to do so.
Last season the Cameroonian scored nine goals and assisted six in 25 games.
The Southampton defence will have to keep a watchful eye on the attacker, especially as Mbeumo will make those dangerous runs in behind the defence, whilst carrying the ball up the field with his pace.
Mbeumo has also formed a partnership with Yoane Wissa, who assisted the attacker for his first goal of the season.
Southampton - Mateus Fernandes
Mateus Fernandes joined the Saints from Sporting CP during this summer transfer window.
The Portuguese midfielder got his first taste of Premier League action when he came on as a substitute at home against Nottingham Forest, where he showed some bits of what he is capable of.
During midweek, he started against Cardiff in the EFL Cup, where he showed the Saints fans what they should expect. He scored just 10 minutes into his full debut with a goal from outside the box, but came off around the 60th-minute mark with a worthy Man of the Match performance under his belt.
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Match Details
Where is the game being played?
The match is being played at the Gtech Community Stadium, the home of Brentford Football Club.
What time is kick-off?
Kick-off is 3PM (BST) on Saturday 31st August.
Where can I watch it?
As this is a 3PM kick-off, the game will not be shown live, but you'll be able to catch highlights on Sky Sports YouTube - or watch longer highlights on Match of the Day at 22:20PM.
