England are looking to secure their route to the knockout stages on match day three, while Wales looking to give themselves a fighting chance of staying in their first World Cup since the 1958 edition of the tournament.
This fixture will mark the first time that England have met a fellow British nation at a World Cup, being the 104th clash between these two. The Three Lions have won the last six in a row, scoring 11 and conceding only once.
Both teams slipped up in contrasting ways on match day two with England playing out a 0-0 stalemate with the USA, as Wales fell to a late 2-0 defeat earlier that same day to Iran.
Wayne Hennessey saw red late in the game for his high challenge on forward Mehdi Taremi as stoppage time saw Team Melli put two past Leicester City goalkeeper Danny Ward.
The possibility of this being Wales final game makes the affair even greater as they play their home nation rivals as they need results elsewhere to go their way as well as pull off a victory here to do the unthinkable.
The group has been more even than many have expected with all four nations still facing the possibility of elimination, a fact that shocks people more with the Three Lions putting six past Iran on opening day.
Wales need to beat England to qualify themselves as well as hope for a draw between the USA and Iran. If there is no draw in that game, they will have to beat England by four goals.
Team News
Both teams are almost at a clean bill of health, however, Rob Page will of course be without number one Hennessey following his red card against Iran so we can expect to see Danny Ward fill in in between the sticks.
Joe Allen featured from the bench against Iran following his hamstring injury but could largely be blamed for the first goal which Iran scored, as his poor clearance gave Rouzbeh Cheshmi the chance to strike from long range.
Kieffer Moore is expected to start, his physical presence gives him the ability to cause problems for the opposition defence and will be motivated for the occasion.
For England, they are relatively injury free, James Maddison has rejoined training following his knee injury picked up on the final day of the Premier League season before the break.
The only player facing the possibility of missing out is Arsenal defender Ben White who missed training through illness on Monday.
Many of Southgate's men had an off night against the USA, with many calling to see Phil Foden come on in place of Mason Mount, a change that the manager seemed reluctant to make.
Foden could start out wide this time around, however, as Bukayo Saka endured a tough night himself. Having played in almost every fixture for his club Arsenal this season, it may be time to give the youngster a rest and see the Manchester City man step in in his place.
Kyle Walker also returned to fitness shortly before this tournament and this could be his first start of the tournament, filling in on the right side of the back four in place of Kieran Trippier.
Players to Watch.
England:
For England, their star man should be their captain, Harry Kane. The skipper is still looking for his first non penalty goal of 2022 for country, but should not be in any danger of losing his starting spot, despite the inclusion of Callum Wilson in the squad.
Kane has not looked to be at his best so far this tournament and went off injured in the opening game against Iran. There was concern of the Tottenham striker missing out on Friday against USA, but a scan on his ankle showed no issues, and he was able to start that game.
He has made an impact this tournament as a playmaker though, setting up two goals in the opening game, as well as his prolific goalscoring at club level scoring 12 in 15 in the league this year.
A player who has looked tired this tournament, something which was expected with the timing of this years World Cup, perhaps it could be time to see Kane rested ready for the knockout stages of this tournament and give Callum Wilson his first start at a major tournament.
Wales:
Wales have a prolific striker of their own who is yet to find his footing, this being Bournemouth striker Kieffer Moore. Struggling to find his goalscoring form since his debut season in the Championship with Cardiff City where he bagged himself 20 goals.
He was still able to earn himself a move to Premier League new boys Bournemouth mid way through last season, scoring four goals since their arrival in the top flight, he has shown his ability to compete at the top level.
Like most of the Wales squad, he is yet to find his footing in this tournament, but this is the perfect chance to do so, this side will know they will become national heroes should the pull off the impossible off.
Moore has been anticipating this encounter since before the tournament began stating in an interview before setting off to Qatar he "can't wait to knock England out".
Expected Lineups
England Pickford, Walker, Maguire, Stones, Shaw, Rice, Henderson, Sterling, Rashford, Foden, Kane
Wales Ward, Mepham, Davies, Rodon, Roberts, Ramsey, Ampadu, Williams, James, Moore, Bale
How to Watch
Where is the game?
The two teams will clash in Al Rayyan in the Ahmed Bin Ali Stadium
When is the game?
Wales vs England kicks off at 7PM UK time on Tuesday November 29th.
How can I watch the game?
In the UK, this game will be broadcast live on BBC One with pre match coverage beginning at 6:00PM.