The Red Devils will be looking to start the campaign on a high to mount a title challenge at the feat of the Premier League table. Having had a mixed pre season losing 4-2 to Queens Park Rangers in West London, drawing 2-2 at home to Brentford and beating Derby County at Pride Park and Everton in Manchester, United will put their form behind them as they take on a fierce Leeds United side under parent manager Marcelo Bielsa.
United finished in 2nd place last season 12 points behind Champions Manchester City but now with new faces in the dressing room, the likes of Raphael Varane and Jadon Sancho have boosted United's hopes this season as they look to break the ice at the top of the league eyeing up an opportunity to compete with the very best teams in English Football in pursuit of silverware.
The Red Devils record against Leeds United is a pretty healthy one. In the last game at Old Trafford, United were unstoppable beating the Whites 6-2. Goals from Scott McTominay, Bruno Fernandes, Victor Lindelof and Daniel James made it an easy win although Liam Cooper and Stuart Dallas did get on the scoresheet for the away side.
Over the course of the Premier League of recent the meeting between both sides shows United have been unbeaten at Old Trafford since 29 February 1981 against the Whites.
Below is all you need to know ahead of the contest.
What team will Ole Gunnar Solskjaer go for in front of returning fans?
New signing Jadon Sancho has enjoyed his first week of training, and could be in contention to make his Premier League debut this weekend, though possibly from the substitutes bench. Anthony Martial started last weekend's 4-0 win in the friendly with Everton and could be in line to feature in a competitive game for the first time in almost five months. Prospective new signing Raphael Varane is still to be confirmed, a similar defensive set up this weekend would not be surprising.
Bruno Fernandes was in fine form last weekend, but who will partner him in the middle of the park? Nemanja Matic, Paul Pogba and Donny Van De Beek have all been looking bright and, in the wide positions, youngster Anthony Elanga has proved he is more than ready to build on the opportunities he received last season. Up top, Mason Greenwood is another option at centre-forward or on the flanks.
Manchester United: De Gea; Wan-Bisakka, Lindelof, Maguire, Shaw, McTominay, Pogba, Greenwood, Fernandes, James, Martial.
Leeds United; Meslier; Ayling, Cooper, Koch, Firpo, Raphinha, Klich, Phillips, Dallas, Harrison, Bamford.