Aston Villa look to repeat their impressive victory on Sunday when they defeated The Red Devils 3-1 at Villa Park in their first game under new boss Unai Emery.
Renowned for his expertise in cup competitions, winning four Europa League trophies already in his managerial career, the former Arsenal manager will be wanting to bring a major trophy to the claret and blue side of Birmingham for the first time since 1996.
The Villans reached the final of the Carabao Cup just three seasons ago under Dean Smith, but stumbled at the last hurdle losing 2-1 to Manchester City.
Erik Ten Hag's side will be out for revenge, however, after their humiliating loss last weekend, and will look to sure up on the areas that Villa were able to exploit.
United are desperate to end their trophy drought, with their last honour being the Europa League back in 2017 when they defeated Ajax in the final.
This is currently their longest period without a trophy in over 40 years.
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Team News
Manchester United:
England winger Jadon Sancho could return on Thursday night after missing out on Sunday through illness.
Four-time Champions League winner Raphael Varane (thigh) remains out and won't be available for United until after the World Cup, however could still make the trip to Qatar.
Portuguese playmaker Bruno Fernandes is back in the fold after missing the weekend through suspension.
Diogo Dalot was booked on Sunday and will miss his side's clash with Fulham, however will be available for selection against Villa.
Brazilian forward Antony should be back after being omitted through injury at the weekend, whilst Brandon Williams and Axel Tuanzebe remain off the pitch with longer term injuries.
Expect some rotation due to it being a cup fixture, however the hosts will be keen to secure revenge and challenge for a trophy this campaign.
Aston Villa:
Former Liverpool midfielder Philippe Coutinho (thigh) missed out on the last match, and won't return until after the World Cup break.
Fellow Brazilian and summer signing Diego Carlos (calf/shin/heel) remains out for the foreseeable future after picking up a serious injury earlier on in the season.
The Villans may also look to rotate, but expect Emery to keep a strong team in place as they look to kick on from their 4-1 win last round against Bolton Wanderers.
With only one game remaining after this game before the World Cup break, away at Brighton in the Premier League, Villa will be keen to go into the month off positively.
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Predicted Lineups
Manchester United:
Dúbravka; Dalot, Maguire, Lindelof, Malacia; Fred, McTominay, Fernandes, Antony, Sancho; Rashford
Aston Villa:
Martínez; Cash, Chambers, Mings, Digne; Luiz, McGinn, Ramsey, Buendía; Bailey, Watkins
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Key Players
Manchester United:
Most likely returning to the side this week, Bruno Fernandes will be aiming to be the difference-maker after being absent for Sunday's loss.
The Portuguese midfielder hasn't hit the heights he once knew so far this year, but has had time to rest during his suspension and will be looking to prove that his absence was a key factor in United's struggle.
With just two goals and one assist to his name in the Premier League this season, Fernandes needs to prove his doubters wrong and improve his output.
The 28-year-old would really benefit from a good performance this week against The Villans, and a significant contribution in a cup run would stand him in good stead.
He only needs to look at the scintillating displays of Manchester City's Kevin De Bruyne to gain the motivation he needs to up his game.
Whether United's no.8 starts or makes a cameo off the bench, plenty of eyes will be on him.
Aston Villa:
Picking up fan-voted Man of the Match awards in both of Aston Villa's last two wins, against United and Brentford respectively, it's hard to look past Leon Bailey as their danger man for this fixture.
The Jamaican was a constant threat to The Red Devils at the weekend, getting in behind the red defence after just seven minutes to put his side a goal ahead.
Bailey is really starting to show why Midlands side signed him just over a year ago with three goals and two assists this season which he'll be keen to improve on.
Playing high up with striker Ollie Watkins worked wonders on Sunday with United struggling to contain the duo, the former Bayer Leverkusen winger will want to replicate his threat and run riot between he opposition's defensive lines.
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Match Details
Where is the game being played?
Old Trafford, the home of Manchester United.
What time is kick off?
The game starts at 8pm, on Thursday, November 10.
Where can I watch the match?
Fans in the UK can watch on Sky Sports via a subscription.