Everton will be looking for their first win in six games when they face Manchester City at the Etihad Stadium on Sunday.
The Toffees drew 0-0 against Tottenham Hotspur last time out, ending a run of three straight defeats.
Their most recent victory was against Norwich City on 25 September, and they go into this clash in 11th place.
Pep Guardiola's men lost 2-0 against Crystal Palace in their last home Premier League match. Since then, they have beaten Club Brugge 4-1 in the Champions League and won 2-0 against fierce rivals Manchester United at Old Trafford.
Tom Davies (knee) will also miss out, while Mason Holgate is suspended following his red card against Tottenham.
Manchester City: Ederson; Walker, Dias, Stones, Cancelo; Gundogan, Rodri, Silva; Mahrez, Jesus, Sterling.
Everton: Pickford; Coleman, Keane, Godfrey, Digne; Townsend, Delph, Allan, Gordon; Gray; Richarlison.
Ones to watch
Silva is the Citizens' joint-top scorer in the league this season with three goals and has also provided one assist.
The Portuguese midfielder operated as a false nine in the win against United and scored City's second goal.
With Guardiola set to be missing De Bruyne, Grealish, Torres and possibly Foden, there will be added pressure on Silva to help his side to victory.
Townsend has scored five goals for Everton in all competitions this season to become their top scorer while also providing three assists.
His last goal came at Old Trafford against City's rivals United, a game the Toffees drew 1-1
Citizens will still remember his stunning strike for Crystal Palace at the Etihad in December 2018, which helped the Eagles win 3-2 and saw Townsend nominated for the Puskas Award.
City have dominated this fixture for over three years, with victory in each of the last eight meetings.
Their last meeting was at the Etihad in May, and the Citizens won 5-0 as Sergio Aguero scored a brace on his final appearance for the club.
Everton's last triumph against Guardiola's men saw them win 4-0 at Goodison Park in January 2017.
In total, they've met 191 times. The Citizens have won 76 compared to the Toffees' 68 - with 47 draws.
Most recent meeting:
How to watch
The match starts at 14:00 GMT on Sunday 21 November 2021 and will be available to watch in the UK on Sky Sports Main Event (401) and Sky Sports Premier League (402).
What the managers have said
City boss Pep Guardiola spoke to the media ahead of the game - here's what he said.
On playing on Sunday: We are used to playing with one less day before,” Guardiola said.
“This is an exception. We didn't complain before. And we won't now.
“If the broadcaster wants us to play Sunday, we play Sunday. Other times we have played Saturday 12:30.”
Guardiola also discussed having players ruled out after the international break.
“I am concerned because we are unlucky, we always have problems when players come back from international break,” he said.
“This is not an exception. All the time we give them fit,- but they can come back not fit. It can happen.”
On challenging for the Premier League title: “We have finished the first quarter of the season – and have many games ahead of us," Guardiola explained.
“In general we made good performances, but we dropped points at home when we were not at our normal level.
“Now, until January, there is no international break and hopefully we can get a point and qualify for the Champions League and fight for the title at the end of the season.
“I would not say the previous seasons when we were champions or close to the top, the race was as difficult as it is now.”
“We know we will be playing against a good team but are confident we can do well,” Benitez said.
“Our last game against Tottenham, the team showed character with the right mentality and that’s what we have to do in every match.
“All the teams in the world need positive results for confidence.
“The fact we did well [in Spurs game] in terms of the intensity and commitment of the players until the last minute was quite positive.
“We did that in a lot of games, especially at Goodison Park.
“I expect the team can get a result [against City] and then if this is the first one [victory since beating Norwich City on 25 September], it would be easy for me to motivate the players for the next games.”